Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing, China.
Research Institute of Otolaryngology, Nanjing, China.
Acta Otolaryngol. 2021 Apr;141(4):419-423. doi: 10.1080/00016489.2020.1869305. Epub 2021 Jan 29.
There were heterogeneous or even conflicting data regarding the ability of platelet-to-lymphocyte ratio (PLR) for predicting the prognosis of laryngeal/hypopharyngeal squamous cell carcinoma (LHSCC). The discrepancies were found to be largely due to the cutoff value of PLR.
The aims of this study were to rationally select an optimal PLR cutoff value and to analyze the relationship between pretreatment PLR and the prognosis.
A total of 180 male patients were eligible for this retrospective study. We included another 180 healthy male individuals as controls. The relationship between PLR and age in patients and the controls was determined. The optimal cutoff values of PLR were identified. PLR value was then dichotomized into two categories, and the relationship between PLR and the clinicopathologic parameters were calculated. Kaplan-Meier curves were used to evaluate the overall survival (OS), and the association between PLR and the OS was analyzed.
The linear regression analysis showed a positive correlation between age and PLR in the control group, but not the patients. The optimal cutoff value of PLR was 112.5. The high PLR value group of patients exhibited significantly decreased OS. PLR was related to prognosis, as revealed by the univariate Cox regression.
Patients with LHSCC have abnormal high PLR, and a high pretreatment PLR portends adverse survival.
血小板与淋巴细胞比值（PLR）预测喉/下咽鳞状细胞癌（LHSCC）预后的能力存在异质性，甚至相互矛盾，差异主要归因于 PLR 的截断值。
本研究旨在合理选择最佳 PLR 截断值，并分析治疗前 PLR 与预后之间的关系。
共纳入 180 名符合条件的男性患者作为研究对象，同时纳入 180 名健康男性作为对照组。分析患者和对照组中 PLR 与年龄的关系，确定最佳 PLR 截断值。将 PLR 值分为两类，计算 PLR 与临床病理参数之间的关系。采用 Kaplan-Meier 曲线评估总生存率（OS），分析 PLR 与 OS 的关系。
线性回归分析显示，对照组中年龄与 PLR 呈正相关，但患者中无此相关性。PLR 的最佳截断值为 112.5。高 PLR 值组患者的 OS 明显降低。单因素 Cox 回归分析显示 PLR 与预后相关。
LHSCC 患者的 PLR 异常升高，治疗前 PLR 升高预示着不良预后。
