Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline, Nanjing, China.
Research Institution of Otolaryngology, Nanjing, China.
Acta Otolaryngol. 2021 May;141(5):537-543. doi: 10.1080/00016489.2021.1891456. Epub 2021 Apr 19.
Patient prognosis in hypopharyngeal carcinoma remains difficult to predict, necessitating new, readily available biomarkers.
Platelet-lymphocyte ratio (PLR)'s effects on recurrence-free survival (RFS) and overall survival (OS) were evaluated in individuals undergoing radical resection for advanced hypopharyngeal squamous cell carcinoma (HSCC).
A total of 89 patients were retrospectively assessed. PLR, and derived neutrophil-lymphocyte (dNLR) and neutrophil-lymphocyte (NLR) ratios were determined based on complete blood count. Then, the prognostic values of PLR, dNLR and NLR were assessed by univariate and multivariate Cox regression analyses adjusted for disease-specific prognostic factors. Endpoints of interest were RFS and OS.
The optimal cutoff of PLR was 98.815, based on which individuals were categorized into the high- (PLR ≥98.815) and low- (PLR <98.815) PLR groups. High PLR ( = .022) had a significant association with reduced RFS, which still showed significance in multivariable analysis (HR = 2.020, 95%CI: 1.076-3.794, = .029). In univariate analysis, PLR ( = .046) and positive surgical margin ( = .021) also had significant associations with OS.
Elevated PLR has associations with increased risk of recurrence and reduced survival in advanced HSCC cases undergoing radical resection. High presurgical PLR may independently predict RFS. Therefore, further multi-institutional prospective studies are needed to better characterize the role of pre-operative blood PLR as prognostic factors in HSCC.
下咽鳞癌患者的预后仍然难以预测，因此需要新的、易于获得的生物标志物。
评估血小板-淋巴细胞比值（PLR）在接受根治性切除术的晚期下咽鳞癌（HSCC）患者中对无复发生存（RFS）和总生存（OS）的影响。
回顾性评估了 89 例患者。根据全血细胞计数确定 PLR 以及衍生的中性粒细胞-淋巴细胞（dNLR）和中性粒细胞-淋巴细胞（NLR）比值。然后，通过单变量和多变量 Cox 回归分析评估 PLR、dNLR 和 NLR 的预后价值，并根据疾病特异性预后因素进行调整。感兴趣的终点是 RFS 和 OS。
基于最佳截断值 98.815，将患者分为高（PLR≥98.815）和低（PLR<98.815）PLR 组。高 PLR（ = .022）与 RFS 降低显著相关，多变量分析仍显示有显著性（HR = 2.020，95%CI：1.076-3.794， = .029）。单变量分析中，PLR（ = .046）和阳性切缘（ = .021）与 OS 也有显著相关性。
在接受根治性切除术的晚期 HSCC 患者中，升高的 PLR 与复发风险增加和生存降低相关。术前高 PLR 可能独立预测 RFS。因此，需要进一步进行多机构前瞻性研究，以更好地描述术前血液 PLR 作为 HSCC 预后因素的作用。
