Meikle A W, Stringham J D, Woodward M G, Nelson J C
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132.
J Clin Endocrinol Metab. 1988 Mar;66(3):588-92. doi: 10.1210/jcem-66-3-588.
Heritability of the variation of the plasma total and unbound T4 (free T4), T3, T4-binding globulin (TBG), and TSH concentrations was investigated in 15 monozygotic and 15 dizygotic male twin pairs. The variability in plasma of total (58%) and free T4 (72%) concentrations was significantly less (P less than 0.01) in the twin pairs than in unrelated men. Half of the variability of T3 (P less than 0.05), TBG (P less than 0.05), and TSH (P less than 0.05) was affected by influences shared by the twin pairs in both monozygotic and dizygotic twin pairs. The heritability index for variability of the plasma total T4 and free T4 was greater than 28% (P less than 0.05), and it was 25% or less for T3 and TBG. Variation in TBG accounted for less than 20% (P less than 0.001) of the variation in thyroid hormone concentrations. The results indicate that familial factors, which are affected by genetic and/or environmental factors, influence the variation of plasma TBG, TSH, T4, free T4, and T3 concentrations among normal men. Genetic factors influenced the variation in plasma T4 and free T4 levels.
在15对同卵男性双胞胎和15对异卵男性双胞胎中，研究了血浆总甲状腺素（T4）、游离甲状腺素（游离T4）、三碘甲状腺原氨酸（T3）、甲状腺素结合球蛋白（TBG）以及促甲状腺激素（TSH）浓度变化的遗传力。双胞胎血浆中总T4（58%）和游离T4（72%）浓度的变异性显著低于非亲属男性（P<0.01）。在同卵和异卵双胞胎中，T3（P<0.05）、TBG（P<0.05）和TSH（P<0.05）变异性的一半受到双胞胎共同因素的影响。血浆总T4和游离T4变异性的遗传力指数大于28%（P<0.05），而T3和TBG的遗传力指数为25%或更低。TBG的变化占甲状腺激素浓度变化的比例不到20%（P<0.001）。结果表明，受遗传和/或环境因素影响的家族因素，影响正常男性血浆中TBG、TSH、T4、游离T4和T3浓度的变化。遗传因素影响血浆T4和游离T4水平的变化。
