Telethon Kids Institute, Nedlands, Western Australia, Australia.
Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Pediatrics. 2021 Feb;147(2). doi: 10.1542/peds.2020-011270.
Early motor impairments have been reported in children with neurodevelopmental disorders (NDD), but it is not clear if early detection of motor impairments can identify children at risk for NDD or how early such impairments might be detected.
To characterize early motor function in children later diagnosed with NDD relative to typically developing children or normative data.
The Cumulative Index to Nursing and Allied Health Literature, Embase, Medline, PsycINFO, and Scopus electronic databases were searched.
Eligible studies were required to include an examination of motor function in children (0-24 months) with later diagnosis of NDD by using standardized assessment tools.
Data were extracted by 4 independent researchers. The quality of the studies was assessed by using the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields checklist.
Twenty-five studies were included in this review; in most of the studies, the authors examined children with later autism spectrum disorder (ASD). Early motor impairments were detected in children later diagnosed with ASD. The meta-analysis results indicated that differences in fine, gross, and generalized motor functions between the later ASD and typically developing groups increased with age. Motor function across different NDD groups was found to be mixed.
Results may not be applicable to children with different types of NDD not reported in this review.
Early motor impairments are evident in children later diagnosed with ASD. More research is needed to ascertain the clinical utility of motor impairment detection as an early transdiagnostic marker of NDD risk.
已有研究报道，神经发育障碍（NDD）患儿存在早期运动障碍，但目前尚不清楚早期运动障碍检测能否识别出有 NDD 风险的儿童，以及早期运动障碍可能在何时被发现。
本研究旨在与正常发育儿童或参照数据比较，明确具有 NDD 临床诊断的儿童的早期运动功能特征。
对 Cumulative Index to Nursing and Allied Health Literature、Embase、Medline、PsycINFO 和 Scopus 电子数据库进行了检索。
纳入研究必须使用标准化评估工具对 NDD 临床诊断后 0-24 月龄儿童的运动功能进行评估。
由 4 名独立研究人员提取数据。使用各种领域原始研究论文质量评估标准清单评估研究质量。
本综述纳入了 25 项研究，其中大多数研究的作者均对后来被诊断为自闭症谱系障碍（ASD）的儿童进行了研究。研究发现，后来被诊断为 ASD 的儿童存在早期运动障碍。荟萃分析结果表明，ASD 组与正常发育组之间精细运动、粗大运动和总体运动功能的差异随年龄增长而增加。不同 NDD 组的运动功能结果各异。
本研究结果可能不适用于本综述中未报道的其他类型的 NDD 患儿。
后来被诊断为 ASD 的儿童存在早期运动障碍。需要进一步研究以明确运动障碍检测作为 NDD 风险的早期跨诊断标志物的临床实用性。
