Centre de recherche Nutrition, Santé et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec City, QC, Canada.
School of Nutrition, Université Laval, Quebec City, QC, Canada.
J Perinatol. 2021 May;41(5):1033-1042. doi: 10.1038/s41372-021-00932-y. Epub 2021 Jan 28.
This study aims to evaluate the association between exposure to gestational diabetes mellitus and growth trajectory from birth to 5 years and to test whether breastfeeding influences this association among children exposed and unexposed to gestational diabetes.
Weight at 0, 6, 12, and 18 months and 2, 3, 4, and 5 years were retrospectively collected for 103 children exposed and 63 children unexposed to gestational diabetes. Weight-for-age z-score was calculated. Mixed linear model for repeated measurements were computed to test whether breastfeeding was associated differently with weight-for-age z-score of children exposed or unexposed to diabetes.
Children exposed to gestational diabetes had greater z-score values at 6 months and 4 and 5 years (p < 0.10). Breastfeeding duration was not associated with weight-for-age z-score trajectory in any children.
Children exposed to gestational diabetes had a different growth trajectory in early life, but breastfeeding duration did not seem to influence this association.
本研究旨在评估从出生到 5 岁期间暴露于妊娠期糖尿病与生长轨迹之间的关系，并检验母乳喂养是否会影响妊娠期糖尿病暴露和未暴露儿童的这种关联。
回顾性收集了 103 名暴露于妊娠期糖尿病和 63 名未暴露于妊娠期糖尿病的儿童的 0、6、12 和 18 个月以及 2、3、4 和 5 岁时的体重。计算体重与年龄的 z 评分。采用重复测量混合线性模型检验母乳喂养是否与糖尿病暴露或未暴露儿童的体重与年龄 z 评分轨迹有不同的相关性。
暴露于妊娠期糖尿病的儿童在 6 个月、4 岁和 5 岁时的 z 评分值更高（p<0.10）。在任何儿童中，母乳喂养持续时间均与体重与年龄的 z 评分轨迹无关。
暴露于妊娠期糖尿病的儿童在生命早期的生长轨迹不同，但母乳喂养持续时间似乎并未影响这种关联。
