Clinical Research Center, Medical University of Bialystok, Poland.
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Poland.
Oxid Med Cell Longev. 2021 Jan 14;2021:8872702. doi: 10.1155/2021/8872702. eCollection 2021.
Nonalcoholic fatty liver disease (NAFLD) is one of the most commonly occurring diseases within western dietary patterns. Usually untreated, it may lead to type 2 diabetes mellitus (T2DM), steatohepatitis (NASH), and hepatocellular carcinoma (HCC). Besides its severe aftermath, up to now, there is no known therapeutic approach to this disease in everyday clinical practice. Most NAFLD patients are encouraged to do physical activities or diet change and remain without pharmacological treatment. In this study, we present phloroglucinol (PHG) as a novel and promising compound in NAFLD treatment. PHG significantly increased the level of enzymatic and nonenzymatic antioxidants both in palmitate and hydrogen peroxide-induced oxidative stress models. Strengthened antioxidative defense reduced the oxidative/nitrosative damage to cell proteins, lipids, and carbohydrates. Furthermore, PHG treatment reduced hepatic steatosis; lowered inflammatory markers, such as NF-B or HIF-1; and inhibited cell apoptosis. Moreover, PHG had a more comprehensive effect than other commonly used antioxidants: N-acetylcysteine (NAC) and -lipoic acid (ALA), suggesting its clinical usability. Therefore, our paper supports the benefits of natural compounds as a therapeutical approach to NAFLD.
非酒精性脂肪性肝病 (NAFLD) 是西方饮食模式中最常见的疾病之一。通常未经治疗，它可能导致 2 型糖尿病 (T2DM)、脂肪性肝炎 (NASH) 和肝细胞癌 (HCC)。除了其严重的后果外，到目前为止，在日常临床实践中，还没有针对这种疾病的已知治疗方法。大多数 NAFLD 患者被鼓励进行体育活动或改变饮食，而不接受药物治疗。在这项研究中，我们提出了根皮苷 (PHG) 作为治疗 NAFLD 的一种新型有前途的化合物。PHG 显著增加了棕榈酸和过氧化氢诱导的氧化应激模型中酶和非酶抗氧化剂的水平。增强的抗氧化防御减少了细胞蛋白质、脂质和碳水化合物的氧化/硝化损伤。此外，PHG 治疗降低了肝脂肪变性；降低了 NF-B 或 HIF-1 等炎症标志物；并抑制了细胞凋亡。此外，PHG 比其他常用的抗氧化剂（如 N-乙酰半胱氨酸 (NAC) 和 -硫辛酸 (ALA)）具有更全面的作用，表明其临床可用性。因此，我们的论文支持将天然化合物作为治疗非酒精性脂肪性肝病的一种方法的益处。
