Chen Pei-Chin, Kuo Yung-Che, Chuong Cheng-Ming, Huang Yen-Hua
Department of Education, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Front Cell Dev Biol. 2021 Jan 12;8:625943. doi: 10.3389/fcell.2020.625943. eCollection 2020.
Stem cells work with their niches harmoniously during development. This concept has been extended to cancer pathology for cancer stem cells (CSCs) or cancer reprogramming. IGF-1R, a classical survival signaling, has been shown to regulate stem cell pluripotency, CSCs, or cancer reprogramming. The mechanism underlying such cell fate determination is unclear. We propose the determination is due to different niches in embryo development and tumor malignancy which modulate the consequences of IGF-1R signaling. Here we highlight the modulations of these niche parameters (hypoxia, inflammation, extracellular matrix), and the targeted stem cells (embryonic stem cells, germline stem cells, and mesenchymal stem cells) and CSCs, with relevance to cancer reprogramming. We organize known interaction between IGF-1R signaling and distinct niches in the double-sided cell fate with emerging trends highlighted. Based on these new insights, we propose that, through targeting IGF-1R signaling modulation, stem cell therapy and cancer stemness treatment can be further explored.
在发育过程中，干细胞与其微环境和谐协作。这一概念已扩展至癌症病理学领域，用于研究癌症干细胞（CSCs）或癌症重编程。胰岛素样生长因子1受体（IGF-1R）作为一种经典的生存信号，已被证明可调节干细胞多能性、癌症干细胞或癌症重编程。然而，这种细胞命运决定的潜在机制尚不清楚。我们认为，这种决定是由于胚胎发育和肿瘤恶性程度中的不同微环境调节了IGF-1R信号传导的结果。在此，我们强调这些微环境参数（缺氧、炎症、细胞外基质）以及靶向干细胞（胚胎干细胞、生殖系干细胞和间充质干细胞）和癌症干细胞的调节作用，及其与癌症重编程的相关性。我们梳理了IGF-1R信号传导与双面细胞命运中不同微环境之间已知的相互作用，并突出了新出现的趋势。基于这些新见解，我们提出，通过靶向IGF-1R信号传导调节，可以进一步探索干细胞治疗和癌症干性治疗。
