Department of Ophthalmology, San Marco Veterinary Clinic and Laboratory, Veggiano, Italy.
Department of Animal Medicine, Production and Health, University of Padova, Legnaro, Italy.
Vet Ophthalmol. 2021 Mar;24(2):185-194. doi: 10.1111/vop.12862. Epub 2021 Jan 29.
To determine the prevalence of ocular fundus abnormalities in cats with a diagnosis of systemic hypertension, to characterize the abnormalities observed, and to evaluate ophthalmoscopic evolution during treatment with amlodipine besylate.
Cats diagnosed as affected by SHP in a 2-year period.
Systemic hypertension was assessed by oscillometric blood pressure measurement, and its etiology was also established. All the cats received an ophthalmic examination, and ocular lesions were classified with a score from 0 (no abnormalities) to 4 (severe abnormalities). All cats received amlodipine besylate by mouth, and those that showed fundus abnormalities were regularly rechecked from 7 to 365 days after diagnosis. Data were statistically analyzed to compare P and P with all the variables and to correlate P and P with the fundus score.
A total of 225 cats were enrolled in the study, and the prevalence of fundus abnormalities was 58.6% (21.2%: grade 1; 18.2%: grade 2; 36.4%: grade 3; and 24.2%: grade 4). Systemic hypertension was diagnosed concurrently with chronic renal failure (60.4%), hyperthyroidism (28.9%), both chronic renal failure and hyperthyroidism (7.6%), and hypertrophic myocardiopathy (3.1%). A significant effect of P values on the fundus score was detected. Amlodipine therapy improved fundus abnormalities in 50% of cases at the 21-day follow-up.
This study showed that fundus abnormalities are common in hypertensive cats at the time of the systemic diagnosis, and most of the abnormalities are moderate to severe. Treatment with amlodipine appeared to improve ophthalmic lesions over time.
确定诊断为系统性高血压的猫眼部眼底异常的患病率，描述所观察到的异常，并评估使用苯磺酸氨氯地平治疗时的眼底变化。
在 2 年期间被诊断患有 SHP 的猫。
通过振荡血压测量评估系统性高血压，并确定其病因。所有猫均接受眼科检查，并根据眼底病变评分从 0（无异常）到 4（严重异常）进行分类。所有猫均口服苯磺酸氨氯地平，对出现眼底异常的猫在诊断后 7 至 365 天定期复查。对数据进行统计学分析，以比较 P 和 P 与所有变量之间的关系，并将 P 和 P 与眼底评分进行相关性分析。
共有 225 只猫纳入研究，眼底异常的患病率为 58.6%（21.2%：1 级；18.2%：2 级；36.4%：3 级；24.2%：4 级）。系统性高血压与慢性肾衰竭（60.4%）、甲状腺功能亢进（28.9%）、慢性肾衰竭和甲状腺功能亢进同时发生（7.6%）和肥厚性心肌病（3.1%）共同发生。P 值对眼底评分有显著影响。在 21 天随访时，氨氯地平治疗使 50%的病例眼底异常得到改善。
本研究表明，在进行系统性诊断时，高血压猫的眼底异常很常见，且大多数异常为中重度。随着时间的推移，氨氯地平治疗似乎可以改善眼部病变。
