Shum D T, McFarlane R M
Pathology Department, Victoria Hospital, London, Ontario, Canada.
J Hand Surg Am. 1988 Jan;13(1):61-7. doi: 10.1016/0363-5023(88)90202-x.
Thirty-seven specimens from the hands of 30 patients with Dupuytren's disease were examined by light microscopy after immunohistochemical staining for the presence of desmin intermediate filaments. Results indicated that desmin-positive cells were present in the proliferative Dupuytren's nodules, and that the number of desmin-positive cells decreased significantly in the fibrous phase of the disease. Also, on the basis of the pattern of distribution of the desmin-positive cells around vessels, we postulate that the desmin-positive cells in Dupuytren's nodules were migrating perivascular smooth muscle cells from the vessel wall. The exact fate of these cells is uncertain, but we hypothesize that these displaced perivascular smooth muscle cells are capable of transforming into collagen-producing, desmin-negative myofibroblasts that form the cellular basis of Dupuytren's lesions.
对30例患有杜普伊特伦挛缩症患者手部的37个标本进行免疫组织化学染色以检测结蛋白中间丝的存在，之后进行光学显微镜检查。结果表明，在增生性杜普伊特伦结节中存在结蛋白阳性细胞，且在疾病的纤维化阶段，结蛋白阳性细胞数量显著减少。此外，基于结蛋白阳性细胞在血管周围的分布模式，我们推测杜普伊特伦结节中的结蛋白阳性细胞是来自血管壁的血管周围平滑肌细胞。这些细胞的确切命运尚不确定，但我们推测这些移位的血管周围平滑肌细胞能够转化为产生胶原蛋白的、结蛋白阴性的肌成纤维细胞，而这些肌成纤维细胞构成了杜普伊特伦病变的细胞基础。
