Gokel J M, Hübner G
Beitr Pathol. 1977 Oct;161(2):166-75. doi: 10.1016/s0005-8165(77)80095-4.
Twenty-one surgically removed specimens of Morbus Dupuytren (M. D.) were studied by light and electron microscopy. The cell type observed in the proliferative phase shows the basic ultrastructural features of fibroblasts, while the majority of the cells in the involutional phase resemble myofibroblasts. Myofibroblasts exhibit ultrastructural characteristics of both smooth muscle cells and fibroblasts and are said to behave functionally like smooth muscle cells. In the residual phase, typical fibrocytes of connective tissue are found. These findings confirm the concept that fibroblasts are capable of converting into myofibroblasts and demonstrate the myofibroblasts represent an intermediate cell type of transitional cellular differentiation. The significance of myofibroblasts for the development of the contracture of M. D. is discussed.
对21个手术切除的掌腱膜挛缩症标本进行了光镜和电镜研究。在增殖期观察到的细胞类型显示出成纤维细胞的基本超微结构特征，而 involutional 期的大多数细胞类似于肌成纤维细胞。肌成纤维细胞表现出平滑肌细胞和成纤维细胞的超微结构特征，据说在功能上表现得像平滑肌细胞。在残留期，发现了结缔组织的典型纤维细胞。这些发现证实了成纤维细胞能够转化为肌成纤维细胞的概念，并证明肌成纤维细胞代表了过渡性细胞分化的中间细胞类型。讨论了肌成纤维细胞在掌腱膜挛缩症挛缩发展中的意义。 （注：“involutional”可能是“退行性”等意思，但原文未明确给出准确释义，这里直接保留英文）
