Department of Pediatrics, Mangla Hospital & Research Center, Shakti Chowk, Bijnor, Uttar Pradesh, 246701, India.
Department of GI Sciences, The Wellcome Trust Research Laboratory, Christian Medical College, Vellore, Tamil Nadu, India.
Indian J Pediatr. 2021 Mar;88(Suppl 1):59-65. doi: 10.1007/s12098-020-03623-2. Epub 2021 Jan 29.
To establish hospital-based surveillance to identify cases of rotavirus (RV) among children < 5 y of age hospitalized for acute gastroenteritis (AGE) and to determine the burden and profile of circulating RV genotypes in the region.
This study was conducted at a tertiary level hospital in Bijnor district of western Uttar Pradesh, India from January 2018 to January 2020. The duly filled case reporting forms and specimens of all the enrolled children were transported in cold chain to the referral laboratory at Christian Medical College (CMC), Vellore on a monthly basis for testing and storage of stool samples as well as data entry and analysis.
A total of 1055 under-5 children admitted with AGE, were enrolled. Proper stool specimens were collected from 932 children. Rotavirus was found positive in 368 (39.5%) stool specimens. Marked seasonality was observed in RV-positive cases with the highest incidence was noticed during winter months. The 0-11 mo age group had the highest incidence of RV-GE followed by 12-23 mo. G1 (42.08%) was the most frequent G-type whereas G1P[8] (26.23%) was the commonest circulating genotype.
The study confirms a significant burden of RV among AGE cases in young children in western Uttar Pradesh. The findings of the study may serve as useful baseline information to the Government of India for assessing vaccine performance after its introduction in the national immunization programmes.
建立基于医院的监测系统，以发现＜5 岁因急性胃肠炎（AGE）住院的儿童中的轮状病毒（RV）病例，并确定该地区循环 RV 基因型的负担和特征。
本研究于 2018 年 1 月至 2020 年 1 月在印度北方邦比诺尔区的一家三级医院进行。每月将所有登记儿童的填写完整的病例报告表和标本用冷链运输到位于维洛尔的基督教医学院（CMC）的转诊实验室进行检测和粪便标本储存，以及数据录入和分析。
共纳入 1055 名＜5 岁因 AGE 住院的儿童。从 932 名儿童中采集了适当的粪便标本。在 368 份（39.5%）粪便标本中发现轮状病毒阳性。RV 阳性病例存在明显的季节性，冬季发病率最高。0-11 月龄组 RV-GE 的发病率最高，其次是 12-23 月龄组。G1（42.08%）是最常见的 G 型，而 G1P[8]（26.23%）是最常见的循环基因型。
该研究证实了北方邦西部＜5 岁儿童 AGE 病例中 RV 的负担较大。研究结果可能为印度政府在国家免疫规划中引入疫苗后评估疫苗效果提供有用的基线信息。
