Department of Pediatrics, Dr Rajendra Prasad Govt Medical College, Distt Kangra, Tanda, Himachal Pradesh, 176001, India.
The Wellcome Trust Research Laboratory, Christian Medical College, Vellore, Tamil Nadu, India.
Indian J Pediatr. 2021 Mar;88(Suppl 1):28-34. doi: 10.1007/s12098-020-03621-4. Epub 2021 Feb 2.
To study epidemiological profile, prevalence, and molecular epidemiology of RVGE in hospitalized under-5 children at a tertiary care teaching rural hospital located in sub-Himalayan belt of Northern India.
This was a hospital-based surveillance study done over 4 y (2016-2019) including under-5 children hospitalized with acute gastroenteritis (AGE). Demographic and clinical parameters were recorded in a pre-designed performa. After consent, stool samples were collected and sent to Christian Medical College (CMC), Vellore for RV screening by enzyme immunoassay (EIA). Each EIA-positive sample was further subjected to G and P typing using published methods.
Out of total 851 included children, rotavirus gastroenteritis (RVGE) was detected in 23.03% (196/851) cases by EIA. The highest incidence for RVGE-positive cases (40.43%) was observed in 2016 with gradual decline over next 3 y. Maximum cases of diarrhea were observed in 12-23 mo age group along with highest rotavirus detection. G3P[8] was most common genotype (46.94%) found, followed by G1P[8] (13.78%), G2P[4] (4.59%), G1P[6] (8.16%) and G9P[4] (3.57%). Mixed genotype was seen in 13.78% of total cases.
This study summarizes the changing trends in the epidemiology of RVGE in Northern India along with the major circulating genotypes postvaccine introduction.
研究印度北部次喜马拉雅带农村三级教学医院住院 5 岁以下儿童轮状病毒肠炎（RVGE）的流行病学特征、流行率和分子流行病学。
这是一项基于医院的监测研究，在 4 年（2016-2019 年）期间进行，包括因急性胃肠炎（AGE）住院的 5 岁以下儿童。在预设计的表格中记录人口统计学和临床参数。在同意后，收集粪便样本并送往基督教医学院（CMC），维洛尔进行酶免疫测定（EIA）检测 RV。每份 EIA 阳性样本均采用已发表的方法进行 G 和 P 分型。
在总共 851 名纳入的儿童中，EIA 检测到轮状病毒胃肠炎（RVGE）占 23.03%（196/851）。2016 年 RVGE 阳性病例的发病率最高（40.43%），随后 3 年逐渐下降。12-23 个月龄组观察到最多的腹泻病例，同时轮状病毒检出率最高。最常见的基因型是 G3P[8]（46.94%），其次是 G1P[8]（13.78%）、G2P[4]（4.59%）、G1P[6]（8.16%）和 G9P[4]（3.57%）。混合基因型占总病例的 13.78%。
本研究总结了印度北部 RVGE 的流行病学变化趋势以及疫苗接种后主要流行基因型。
