癌症中的自组织：对组织病理学、癌细胞生物学和转移的影响。
Self-organization in cancer: Implications for histopathology, cancer cell biology, and metastasis.
机构信息
Cancer Research Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Cancer Cell. 2021 Apr 12;39(4):443-446. doi: 10.1016/j.ccell.2021.01.010. Epub 2021 Jan 28.
PMID:33513348
Abstract
Pathologists use histological features to classify tumors and assign site of origin for metastasis. How and why tumors organize the way they do and recreate their histological organization during metastasis is unknown. Here, I discuss the concept of "histostasis" conferring tumors a histological memory and hypothesize its implications for metastasis.
摘要
病理学家利用组织学特征对肿瘤进行分类，并确定转移的起源部位。肿瘤如何以及为何以这种方式组织，以及在转移过程中如何重新创建其组织学结构，目前尚不清楚。在这里，我讨论了“组织静止状态”赋予肿瘤组织学记忆的概念，并假设其对转移的影响。
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