Xia Zhenxing, Mu Weiwei, Yuan Shijun, Fu Shunli, Liu Yongjun, Zhang Na
NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Jinan 250012, China.
Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan 250012, China.
Pharmaceutics. 2023 Dec 13;15(12):2770. doi: 10.3390/pharmaceutics15122770.
Nano-delivery systems have demonstrated great promise in the therapy of cancer. However, the therapeutic efficacy of conventional nanomedicines is hindered by the clearance of the blood circulation system and the physiological barriers surrounding the tumor. Inspired by the unique capabilities of cells within the body, such as immune evasion, prolonged circulation, and tumor-targeting, there has been a growing interest in developing cell membrane biomimetic nanomedicine delivery systems. Cell membrane modification on nanoparticle surfaces can prolong circulation time, activate tumor-targeting, and ultimately improve the efficacy of cancer treatment. It shows excellent development potential. This review will focus on the advancements in various cell membrane nano-drug delivery systems for cancer therapy and the obstacles encountered during clinical implementation. It is hoped that such discussions will inspire the development of cell membrane biomimetic nanomedical systems.
纳米递送系统在癌症治疗中已展现出巨大的潜力。然而，传统纳米药物的治疗效果受到血液循环系统的清除作用以及肿瘤周围生理屏障的阻碍。受体内细胞独特能力（如免疫逃逸、延长循环时间和肿瘤靶向性）的启发，开发细胞膜仿生纳米药物递送系统的兴趣日益浓厚。纳米颗粒表面的细胞膜修饰可以延长循环时间，激活肿瘤靶向性，并最终提高癌症治疗的效果。它显示出优异的发展潜力。本综述将聚焦于用于癌症治疗的各种细胞膜纳米药物递送系统的进展以及临床实施过程中遇到的障碍。希望此类讨论能够激发细胞膜仿生纳米医学系统的发展。
