Department of Psychology, University of Arizona, Tucson, AZ, USA.
Sleep and Health Research Program, Department of Psychiatry, University of Arizona, Tucson, AZ, USA.
Neurosci Biobehav Rev. 2021 Apr;123:215-229. doi: 10.1016/j.neubiorev.2020.12.024. Epub 2021 Jan 26.
We conducted a meta-analysis of papers published over the past half-century (1964-2017) that quantified the phase-shifting effects of timed light exposure on rodent locomotor rhythms. Descriptive statistics were tabulated in order to explore the extent to which these studies were generalizable across species, sex, age, circadian timing, and light sources. Attempts at understanding photic resetting were primarily targeted at younger male animals, with particular emphases placed on characterizing the pacemaker systems of C57BL/6 mice and Syrian hamsters during the parts of their subjective night most sensitive to delivery of white-fluorescent light. With subsequent analyses restricted to these rodent models, we then assessed the relationship between luminous exposure (via broadspectrum emission) and phase-shifting through a series of linear regressions. Monotonically increasing illuminance-response functions were noted at most circadian times surveyed. In the aggregate, our results show that previous research conducted on light's regulation of circadian timekeeping has been skewed in design with respect to several important biological variables. This bias might limit translation of phototherapy-relevant data to women and older individuals.
我们对半世纪以来（1964 年至 2017 年）发表的定量研究光时程刺激对啮齿类动物活动节律的相位转变效应的文献进行了荟萃分析。为了探索这些研究在多大程度上可以推广到不同物种、性别、年龄、昼夜节律和光源，我们对描述性统计数据进行了制表。对光重置的理解主要针对年轻雄性动物，特别强调在其主观夜晚最敏感的部分描述 C57BL/6 小鼠和叙利亚仓鼠的生物钟系统，以输送白色荧光光。随后，我们将分析仅限于这些啮齿动物模型，通过一系列线性回归评估光暴露（通过广谱发射）与相位转变之间的关系。在大多数调查的昼夜节律时间点，都注意到单调递增的光照反应函数。总的来说，我们的结果表明，以前关于光对生物钟调控的研究在设计上存在几个重要生物学变量的偏差。这种偏差可能会限制光疗相关数据在女性和老年人中的转化。
