昼夜节律时钟电路中性别差异的研究。
Sex differences in daily timekeeping and circadian clock circuits.
机构信息
Marquette University, Department of Biomedical Sciences, Milwaukee, WI, USA.
Marquette University, Department of Biomedical Sciences, Milwaukee, WI, USA.
出版信息
Semin Cell Dev Biol. 2022 Jun;126:45-55. doi: 10.1016/j.semcdb.2021.04.026. Epub 2021 May 14.
Abstract
The circadian system regulates behavior and physiology in many ways important for health. Circadian rhythms are expressed by nearly every cell in the body, and this large system is coordinated by a central clock in the suprachiasmatic nucleus (SCN). Sex differences in daily rhythms are evident in humans and understanding how circadian function is modulated by biological sex is an important goal. This review highlights work examining effects of sex and gonadal hormones on daily rhythms, with a focus on behavior and SCN circuitry in animal models commonly used in pre-clinical studies. Many questions remain in this area of the field, which would benefit from further work investigating this topic.
摘要
昼夜节律系统以多种方式调节行为和生理，这些方式对健康很重要。几乎身体内的每一个细胞都表达昼夜节律，这个庞大的系统由视交叉上核（SCN）中的中央时钟协调。昼夜节律的性别差异在人类中很明显，了解生物性别如何调节昼夜节律功能是一个重要目标。这篇综述强调了检查性和性腺激素对日常节律的影响的工作，重点是动物模型中的行为和 SCN 电路，这些模型常用于临床前研究。该领域仍有许多问题悬而未决，进一步研究这一课题将从中受益。
相似文献
1
Sex differences in daily timekeeping and circadian clock circuits.昼夜节律时钟电路中性别差异的研究。
Semin Cell Dev Biol. 2022 Jun;126:45-55. doi: 10.1016/j.semcdb.2021.04.026. Epub 2021 May 14.
2
Vasopressin regulates daily rhythms and circadian clock circuits in a manner influenced by sex.加压素以受性别影响的方式调节日常节律和昼夜节律时钟回路。
Horm Behav. 2021 Jan;127:104888. doi: 10.1016/j.yhbeh.2020.104888. Epub 2020 Dec 14.
3
The central circadian timing system.中央生物钟计时系统。
Curr Opin Neurobiol. 2013 Oct;23(5):747-51. doi: 10.1016/j.conb.2013.04.004. Epub 2013 May 22.
4
The clock shop: coupled circadian oscillators.钟表店：耦合的生物钟振荡器。
Exp Neurol. 2013 May;243:21-7. doi: 10.1016/j.expneurol.2012.10.011. Epub 2012 Oct 23.
5
Collective timekeeping among cells of the master circadian clock.主生物钟细胞间的集体计时
J Endocrinol. 2016 Jul;230(1):R27-49. doi: 10.1530/JOE-16-0054. Epub 2016 May 6.
6
In synch but not in step: Circadian clock circuits regulating plasticity in daily rhythms.同步但不同步：调节日常节律可塑性的生物钟回路
Neuroscience. 2016 Apr 21;320:259-80. doi: 10.1016/j.neuroscience.2016.01.072. Epub 2016 Feb 6.
7
Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms.产生神经介素S的神经元在视交叉上核中充当重要的起搏器，以耦合时钟神经元并决定昼夜节律。
Neuron. 2015 Mar 4;85(5):1086-102. doi: 10.1016/j.neuron.2015.02.006.
8
Gonadal- and sex-chromosome-dependent sex differences in the circadian system.性腺和性染色体依赖性昼夜节律系统中的性别差异。
Endocrinology. 2013 Apr;154(4):1501-12. doi: 10.1210/en.2012-1921. Epub 2013 Feb 25.
9
Gonadectomy reveals sex differences in circadian rhythms and suprachiasmatic nucleus androgen receptors in mice.性腺切除术揭示了小鼠昼夜节律和视交叉上核雄激素受体中的性别差异。
Horm Behav. 2008 Mar;53(3):422-30. doi: 10.1016/j.yhbeh.2007.11.014. Epub 2007 Dec 4.
10
Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.星形胶质细胞通过谷氨酸能信号传导控制视交叉上核中的昼夜节律计时。
Neuron. 2017 Mar 22;93(6):1420-1435.e5. doi: 10.1016/j.neuron.2017.02.030. Epub 2017 Mar 9.
引用本文的文献
1
Effects of DNA methylation inhibitors on light-induced circadian clock plasticity.DNA甲基化抑制剂对光诱导的昼夜节律钟可塑性的影响。
Neurobiol Sleep Circadian Rhythms. 2025 Aug 13;19:100134. doi: 10.1016/j.nbscr.2025.100134. eCollection 2025 Nov.
2
The SnackerTracker: A novel home-cage monitoring device for measuring food-intake and food-seeking behaviour in mice.零食追踪器：一种用于测量小鼠食物摄入量和觅食行为的新型笼内监测装置。
Wellcome Open Res. 2025 Jul 23;10:172. doi: 10.12688/wellcomeopenres.23850.2. eCollection 2025.
3
Comparative Analysis of Diel and Circadian Eclosion Rhythms and Clock Gene Expression Between Sexes in the Migratory Moth .迁飞性蛾类雌雄间昼夜及昼夜节律羽化节律与生物钟基因表达的比较分析
Insects. 2025 Jul 9;16(7):705. doi: 10.3390/insects16070705.
4
A repeatedly evolved mutation in Cryptochrome-1 of subterranean animals alters behavioral and molecular circadian rhythms.穴居动物隐花色素-1中反复进化的突变改变了行为和分子昼夜节律。
iScience. 2025 Jun 12;28(7):112874. doi: 10.1016/j.isci.2025.112874. eCollection 2025 Jul 18.
5
Short-Term Evolutionary Features and Circadian Clock-Modulated Gene Expression Analysis of , , and in a Romanian Population of .罗马尼亚某人群中[具体物种1]、[具体物种2]和[具体物种3]的短期进化特征及生物钟调节基因表达分析
Insects. 2025 Jun 4;16(6):591. doi: 10.3390/insects16060591.
6
A circadian behavioral analysis suite for real-time classification of daily rhythms in complex behaviors.一种用于对复杂行为中的日常节律进行实时分类的昼夜行为分析套件。
Cell Rep Methods. 2025 May 19;5(5):101050. doi: 10.1016/j.crmeth.2025.101050.
7
Circadian rhythms are more resilient to pacemaker neuron disruption in female Drosophila.昼夜节律对雌性果蝇起搏器神经元的破坏更具弹性。
PLoS Biol. 2025 May 6;23(5):e3003146. doi: 10.1371/journal.pbio.3003146. eCollection 2025 May.
8
Evaluation of the Digital Ventilated Cage® system for circadian phenotyping.用于昼夜节律表型分析的数字通风笼系统评估
Sci Rep. 2025 Jan 29;15(1):3674. doi: 10.1038/s41598-025-87530-6.
9
Effects of sex, mating status, and genetic background on circadian behavior in .性别、交配状态和遗传背景对……昼夜节律行为的影响
Front Neurosci. 2025 Jan 8;18:1532868. doi: 10.3389/fnins.2024.1532868. eCollection 2024.
10
Incidence of alternative splicing associated with sex and opioid effects in the axon guidance pathway.轴突导向通路中与性别及阿片类药物作用相关的可变剪接发生率。
Gene. 2025 Mar 20;942:149215. doi: 10.1016/j.gene.2025.149215. Epub 2025 Jan 3.
本文引用的文献
1
Meta-analysis of light and circadian timekeeping in rodents.啮齿动物的光和昼夜节律计时的荟萃分析。
Neurosci Biobehav Rev. 2021 Apr;123:215-229. doi: 10.1016/j.neubiorev.2020.12.024. Epub 2021 Jan 26.
2
Vasopressin regulates daily rhythms and circadian clock circuits in a manner influenced by sex.加压素以受性别影响的方式调节日常节律和昼夜节律时钟回路。
Horm Behav. 2021 Jan;127:104888. doi: 10.1016/j.yhbeh.2020.104888. Epub 2020 Dec 14.
3
Rapid Jetlag Resetting of Behavioral, Physiological, and Molecular Rhythms in Proestrous Female Mice.快速重置发情前期雌性小鼠的行为、生理和分子节律。
J Biol Rhythms. 2020 Dec;35(6):612-627. doi: 10.1177/0748730420965291. Epub 2020 Nov 3.
4
Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions.内在光敏感视网膜神经节细胞的多样性：回路与功能。
Cell Mol Life Sci. 2021 Feb;78(3):889-907. doi: 10.1007/s00018-020-03641-5. Epub 2020 Sep 23.
5
Staging of the estrous cycle and induction of estrus in experimental rodents: an update.实验啮齿动物发情周期的分期与发情诱导：最新进展
Fertil Res Pract. 2020 Mar 14;6:5. doi: 10.1186/s40738-020-00074-3. eCollection 2020.
6
Sex differences in circadian endocrine rhythms: Clinical implications.昼夜节律性内分泌节律的性别差异：临床意义。
Eur J Neurosci. 2020 Jul;52(1):2575-2585. doi: 10.1111/ejn.14692. Epub 2020 Feb 28.
7
Sex differences in the circadian misalignment effects on energy regulation.昼夜节律失调对能量调节的性别差异。
Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23806-23812. doi: 10.1073/pnas.1914003116. Epub 2019 Nov 4.
8
The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep.前脑突触转录组受时钟调控，但蛋白质组受睡眠驱动。
Science. 2019 Oct 11;366(6462). doi: 10.1126/science.aav2642.
9
Physiological, behavioral and environmental factors influence bifurcated circadian entrainment in mice.生理、行为和环境因素影响小鼠的分支昼夜节律调节。
Physiol Behav. 2019 Oct 15;210:112625. doi: 10.1016/j.physbeh.2019.112625. Epub 2019 Jul 17.
10
Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases.限时进食预防和治疗慢性代谢性疾病。
Annu Rev Nutr. 2019 Aug 21;39:291-315. doi: 10.1146/annurev-nutr-082018-124320. Epub 2019 Jun 10.
Zotero 插件