Research Center for Functional Genomics Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Centiv DE, Bremen, Germany.
Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166045. doi: 10.1016/j.bbadis.2020.166045. Epub 2021 Jan 26.
Circular RNAs (circRNA) have gained recent interest due to their functional versatility due to their interactions with other RNA species and proteins, all of which underline complex regulatory networks involved in pathogenic mechanisms. As a result, recent insights in circRNA biology are investigating their biomarker and therapeutic potential. One such circRNA is CircFOXO3, which consists of the circularized second exon of the FOXO3 mRNA, a member of the forkhead box transcription factor family involved in the regulation of developmental programs. Recent research focused on the role of circFOXO3 in the context of cancer has highlighted several implications in key tumorigenesis mechanisms, thus consolidating its relevance among other identified circRNAs. In this paper, we will focus on the currently identified case-specific implications of circFOXO3 in cancer, with a focus on the circFOXO3-miRNA-mRNA regulatory networks, its interactions with different proteins, and their cumulated biological effects upon tumor development. Therefore, we aim to provide an integrated perspective of the mechanistic implications of circFOXO3 in different cancers while also highlighting its biomarker or therapeutic potential based on the current evidence.
环状 RNA（circRNA）因其与其他 RNA 种类和蛋白质的相互作用而具有多功能性，这都突显了参与致病机制的复杂调控网络，因此最近人们对 circRNA 的生物学特性产生了浓厚的兴趣，正在研究其作为生物标志物和治疗靶点的潜力。其中一种环状 RNA 是 CircFOXO3，它由 FOXO3 mRNA 的第二个外显子环化而成，FOXO3 是叉头框转录因子家族的成员，参与调控发育程序。最近的研究集中在 circFOXO3 在癌症背景下的作用，强调了其在关键肿瘤发生机制中的几种作用，从而使其与其他已鉴定的 circRNAs 一样具有相关性。在本文中，我们将重点关注 circFOXO3 在癌症中目前已确定的特定案例的影响，重点关注 circFOXO3-miRNA-mRNA 调控网络、其与不同蛋白质的相互作用以及它们对肿瘤发展的累积生物学效应。因此，我们旨在提供对 circFOXO3 在不同癌症中的机制影响的综合视角，同时根据现有证据强调其作为生物标志物或治疗靶点的潜力。
