Platten Martin, Cranen Rita, Peters Claudia, Wisplinghoff Hilmar, Nienhaus Albert, Bach Alexander Daniel, Michels Guido
Labor Dr. Wisplinghoff, Köln, Deutschland.
Arbeitsmedizin, St.-Antonius-Hospital Eschweiler, Eschweiler, Deutschland.
Dtsch Med Wochenschr. 2021 Mar;146(5):e30-e38. doi: 10.1055/a-1322-5355. Epub 2021 Jan 29.
We assessed the prevalence of SARS-CoV-2 in the staff of a general hospital in North-Rhine-Westphalia in a cross-sectional study.
Employees (n = 1363) were offered a nasopharyngeal swab and serology for SARS-CoV-2. Additionally, employees completed a questionnaire about preexisting conditions, contacts with SARS-CoV-2-positive individuals and COVID-19-specific symptoms.
1212 employees participated. 19 of 1363 (1.4 %) employees tested positive by PCR (3 within and 16 before the study). 40 (3.3 %) and 105 (8.6 %) had IgG and IgA, respectively, 32 (2.6 %) both IgG and IgA. Overall, 47 employees tested positive. In this group, most frequently reported symptoms were headache (56 %), fatigue (49 %), sore throat (49 %), and cough (46 %); fever was reported by 33 %. SARS-CoV-2-positive employees reported more frequently contact with COVID-19 cases (60.5 % vs. 37.3 %, p = 0.006). Employees testing positive only for IgA reported less symptoms.
Between 27.04. and 20.05.2020, 3.9 % of the employees working in a general hospital were tested positive for SARS-CoV-2. This proportion was lower than expected; possible explanations are the low level of endemic infection and the extensive, uniform in-house preventative measures.
在一项横断面研究中，我们评估了北莱茵-威斯特法伦州一家综合医院工作人员中SARS-CoV-2的流行情况。
为1363名员工提供了SARS-CoV-2的鼻咽拭子检测和血清学检测。此外，员工还完成了一份关于既往病史、与SARS-CoV-2阳性个体接触情况以及COVID-19特异性症状的问卷。
1212名员工参与。1363名员工中有19名（1.4%）通过PCR检测呈阳性（研究期间内3名，研究前16名）。分别有40名（3.3%）和105名（8.6%）员工IgG和IgA呈阳性，32名（2.6%）员工IgG和IgA均呈阳性。总体而言，47名员工检测呈阳性。在这组员工中，最常报告的症状是头痛（56%）、疲劳（49%）、喉咙痛（49%）和咳嗽（46%）；33%的员工报告有发热症状。SARS-CoV-2阳性员工报告与COVID-19病例接触的频率更高（60.5%对37.3%，p = 0.006）。仅IgA呈阳性的员工报告的症状较少。
在2020年4月27日至5月20日期间，一家综合医院3.9%的工作人员SARS-CoV-2检测呈阳性。这一比例低于预期；可能的解释是地方感染水平较低以及广泛、统一的内部预防措施。
