Stüven Philipp, Mühlenbruch Georg, Evenschor-Ascheid Agnes, Conzen Ellen, Peters Claudia, Schablon Anja, Nienhaus Albert
University Hospital Hamburg-Eppendorf (UKE), Institute for Health Services Research in Dermatology and Nursing (IVDP), Centre for Epidemiology and Health Services Research for Healthcare Professionals (CVcare), Hamburg, Germany.
Rhine-Maas Hospital, District Aachen, Würselen, Germany.
GMS Hyg Infect Control. 2022 Mar 1;17:Doc04. doi: 10.3205/dgkh000407. eCollection 2022.
Hospital staff have an increased risk of SARS-CoV-2 infection. It is thus necessary to monitor the situation because infected staff may in turn infect patients and their family members. Following the first wave of infection in the summer of 2020, the Rhine-Maas Hospital (RMK) provided all staff the opportunity to be tested for SARS-COV-2 via antibody testing. The tests were carried out from 19.6.2020 to 17.7.2020. The IgG antibody test qualitatively tested for SARS-CoV-2 antibodies via enzyme-linked immunosorbent assay (ELISA). An IgG titre of 0.8 IU/mL or more was considered positive. All staff who tested positive for SARS-CoV-2 by PCR testing after February 2020 were also included in the study. Occupational and non-occupational risk factors for infection were determined. Staff in the intensive care ward, the emergency depart-ment, or a SARS-CoV-2 ward ("corona ward") were predefined as having increased exposure. Odds ratios (OR) were calculated using logistical regression for occupational and private infection risk. 903 staff members (58.9%) with complete data took part in the cross-sectional study. 52 staff members (5.8%) had a positive PCR test result in their medical history or tested positive in the IgG test. Around half of the infections (55%) were only detected by serological testing during the study. Staff with tasks classified as at-risk had an OR of 1.9 (95% CI 1.04-3.5) for infection. Risk factors also included private contacts to people infected with SARS-CoV-2 and holidays in risk areas. At the time of data collection, 11.5% of those with the disease reported that they had not yet fully recovered from COVID-19. Following the first COVID-19 wave, 5.3% of staff at the RMK were infected. An increase in occupational infection risk was found even after controlling for non-occupational infection risks. This should be taken into account with regard to the recognition of COVID-19 as an occupational disease. Methods to improve protection against nosocomial transmissions should be considered.
医院工作人员感染新型冠状病毒的风险增加。因此，有必要对这种情况进行监测，因为受感染的工作人员可能会反过来感染患者及其家属。在2020年夏季的第一波感染之后，莱茵-马斯医院（RMK）为所有工作人员提供了通过抗体检测来检测新型冠状病毒的机会。检测于2020年6月19日至2020年7月17日进行。IgG抗体检测通过酶联免疫吸附测定（ELISA）对新型冠状病毒抗体进行定性检测。IgG滴度为0.8 IU/mL或更高被视为阳性。2020年2月之后通过PCR检测新型冠状病毒呈阳性的所有工作人员也被纳入该研究。确定了感染的职业和非职业风险因素。重症监护病房、急诊科或新型冠状病毒病房（“新冠病房”）的工作人员被预先定义为暴露增加。使用逻辑回归计算职业和个人感染风险的比值比（OR）。903名（58.9%）有完整数据的工作人员参与了这项横断面研究。52名（5.8%）工作人员在其病史中有PCR检测阳性结果或IgG检测呈阳性。在研究期间，约一半（55%）的感染仅通过血清学检测发现。被归类为有风险任务的工作人员感染的OR为1.9（95%置信区间1.04 - 3.5）。风险因素还包括与感染新型冠状病毒的人的私人接触以及在风险地区度假。在数据收集时，11.5%的患病人员报告称他们尚未从新冠病毒疾病中完全康复。在第一波新冠疫情之后，RMK医院5.3%的工作人员被感染。即使在控制了非职业感染风险之后，仍发现职业感染风险有所增加。在将新冠病毒疾病认定为职业病方面应考虑到这一点。应考虑改善针对医院内传播的防护方法。
