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PM 暴露对超重或肥胖人群生物钟基因甲基化的影响。

Effects of PM Exposure on the Methylation of Clock Genes in a Population of Subjects with Overweight or Obesity.

机构信息

Department of Preventive Medicine, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

EPIGET-Epidemiology, Epigenetics and Toxicology Lab., Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy.

出版信息

Int J Environ Res Public Health. 2021 Jan 27;18(3):1122. doi: 10.3390/ijerph18031122.

DOI:10.3390/ijerph18031122
PMID:33513987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7908270/
Abstract

The expression of clock genes, regulating the synchronization of metabolic and behavioral processes with environmental light/dark cycles, is regulated by methylation and might be influenced by short-term exposure to airborne particulate matter (PM), especially in individuals that are hypersensitive to proinflammatory cues. The present study aimed to evaluate the effects of PM and PM on the methylation profile of the clock genes , , , , , , and in a population of 200 women with obesity. A significant association between PM exposure and the methylation of clock genes was found, namely, this was negative for gene and positive for the , , , and genes. PM was negatively associated with methylation of gene and positively with methylation of gene. Evidence was observed for effect modification from body mass index (BMI) regarding the gene: as PM increases, DNA methylation increases significantly for relatively low BMI values (BMI = 25), while it decreases in participants with severe obesity (BMI = 51). PM may therefore alter the epigenetic regulation of clock genes, possibly affecting circadian rhythms. Future studies are needed to clarify how alterations in clock gene methylation are predictive of disease development and how obesity can modulate the adverse health effects of PM.

摘要

时钟基因的表达调节代谢和行为过程与环境光/暗周期的同步，受甲基化调控，可能会受到短期暴露于空气传播的颗粒物（PM）的影响，特别是在对促炎信号敏感的个体中。本研究旨在评估 PM 和 PM 对肥胖人群中 200 名女性时钟基因 、 、 、 、 、 的甲基化谱的影响。发现 PM 暴露与时钟基因的甲基化之间存在显著关联，即 基因的甲基化呈负相关，而 、 、 和 基因的甲基化呈正相关。PM 与 基因的甲基化呈负相关，与 基因的甲基化呈正相关。关于 基因，观察到体重指数（BMI）的效应修饰证据：随着 PM 的增加，相对较低的 BMI 值（BMI = 25）的 DNA 甲基化显著增加，而肥胖程度严重的参与者（BMI = 51）的 DNA 甲基化则降低。因此，PM 可能会改变时钟基因的表观遗传调控，可能会影响昼夜节律。需要进一步的研究来阐明时钟基因甲基化的改变如何预测疾病的发展，以及肥胖如何调节 PM 的不良健康影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01aa/7908270/1124e0b52adc/ijerph-18-01122-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01aa/7908270/8e6010031604/ijerph-18-01122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01aa/7908270/eac3353b61b3/ijerph-18-01122-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01aa/7908270/1124e0b52adc/ijerph-18-01122-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01aa/7908270/8e6010031604/ijerph-18-01122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01aa/7908270/eac3353b61b3/ijerph-18-01122-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01aa/7908270/1124e0b52adc/ijerph-18-01122-g003.jpg

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本文引用的文献

1
The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis.颗粒物与炎症及血液凝固标志物的短期和长期关联：一项荟萃分析。
Environ Pollut. 2020 Dec;267:115630. doi: 10.1016/j.envpol.2020.115630. Epub 2020 Sep 10.
2
The circadian clock and inflammation: A new insight.昼夜节律时钟与炎症：新见解
Clin Chim Acta. 2021 Jan;512:12-17. doi: 10.1016/j.cca.2020.11.011. Epub 2020 Nov 23.
3
Circadian Rhythm in Adipose Tissue: Novel Antioxidant Target for Metabolic and Cardiovascular Diseases.
Genetic Variations and Altered Blood mRNA Level of Circadian Genes and BDNF as Risk Factors of Post-Stroke Cognitive Impairment Among Eastern Indians.
作为印度东部人群中风后认知障碍风险因素的昼夜节律基因和脑源性神经营养因子的基因变异及血液mRNA水平改变
Neuromolecular Med. 2023 Dec;25(4):586-595. doi: 10.1007/s12017-023-08761-2. Epub 2023 Oct 9.
4
Air Pollution and Perinatal Mental Health: A Comprehensive Overview.空气污染与围产期心理健康：全面概述
J Clin Med. 2023 Apr 27;12(9):3146. doi: 10.3390/jcm12093146.
5
Fine particulate matter (PM)-induced pulmonary oxidative stress contributes to increases in glucose intolerance and insulin resistance in a mouse model of circadian dyssynchrony.细颗粒物 (PM) 引起的肺部氧化应激导致昼夜节律失调小鼠模型中葡萄糖耐量降低和胰岛素抵抗增加。
Sci Total Environ. 2023 Jun 15;877:162934. doi: 10.1016/j.scitotenv.2023.162934. Epub 2023 Mar 18.
6
Association between night shift work and methylation of a subset of immune-related genes.夜班工作与免疫相关基因亚组甲基化的关联。
Front Public Health. 2023 Jan 12;10:1083826. doi: 10.3389/fpubh.2022.1083826. eCollection 2022.
7
Changes in DNA Methylation of Genes in Obese Adolescents after a Short-Term Body Weight Reduction Program: A Possible Metabolic and Endocrine Chrono-Resynchronization.短期体重减轻方案对肥胖青少年基因 DNA 甲基化的影响：一种可能的代谢和内分泌时间重同步化。
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10
The Methylation of Clock Genes in Perinatal Depression: Which Role for Oxytocin?围产期抑郁症中生物钟基因的甲基化：催产素起何种作用？
Front Psychiatry. 2021 Sep 28;12:734825. doi: 10.3389/fpsyt.2021.734825. eCollection 2021.
脂肪组织中的昼夜节律：代谢性疾病和心血管疾病的新型抗氧化靶点
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4
Adolescent sleep timing and dietary patterns in relation to DNA methylation of core circadian genes: a pilot study of Mexican youth.青少年的睡眠时机和饮食模式与核心生物钟基因的 DNA 甲基化的关系：一项对墨西哥青少年的初步研究。
Epigenetics. 2021 Aug;16(8):894-907. doi: 10.1080/15592294.2020.1827719. Epub 2020 Oct 4.
5
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Curr Genomics. 2019 Aug;20(5):332-339. doi: 10.2174/1389202919666191014094349.
6
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Int J Mol Sci. 2020 Apr 27;21(9):3090. doi: 10.3390/ijms21093090.
7
The importance of language in engagement between health-care professionals and people living with obesity: a joint consensus statement.语言在医患互动中的重要性：肥胖患者与医疗保健专业人员共同达成的共识声明。
Lancet Diabetes Endocrinol. 2020 May;8(5):447-455. doi: 10.1016/S2213-8587(20)30102-9.
8
Ambient fine particulate matter exposure perturbed circadian rhythm and oscillations of lipid metabolism in adipose tissues.环境细颗粒物暴露扰乱了脂肪组织中昼夜节律和脂质代谢的波动。
Chemosphere. 2020 Jul;251:126392. doi: 10.1016/j.chemosphere.2020.126392. Epub 2020 Feb 29.
9
Ambient fine particulate matter disrupts hepatic circadian oscillation and lipid metabolism in a mouse model.环境细颗粒物扰乱小鼠模型肝脏的昼夜节律振荡和脂质代谢。
Environ Pollut. 2020 Jul;262:114179. doi: 10.1016/j.envpol.2020.114179. Epub 2020 Feb 28.
10
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