School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Int J Mol Sci. 2021 Jan 27;22(3):1262. doi: 10.3390/ijms22031262.
species are used as medicinal plants and contain lanosterol-type triterpene glycosides. The phytochemical investigation of the bulbs of led to the isolation of 17 compounds, including three new rearranged pentacyclic-lanosterol glycosides (1-3) and two new homoisoflavanone glycosides (12 and 13). The structures of the undescribed compounds were determined by extensive spectroscopic analyses, including two-dimensional (2D) NMR. Among the triterpene glycosides, 2, 3, and 6 showed significant pancreatic lipase inhibitory activity in a concentration-dependent manner in vitro. The oral administration of scillascilloside D-2 (6) reduced serum triglyceride levels in a dose-dependent manner in soybean oil-loaded mice.
一些物种被用作药用植物，含有羊毛甾烷型三萜糖苷。对 的鳞茎进行的植物化学研究导致分离出 17 种化合物，包括三种新的重排五环羊毛甾烷糖苷（1-3）和两种新的异黄烷酮糖苷（12 和 13）。未描述的化合物的结构通过广泛的光谱分析确定，包括二维（2D）NMR。在三萜糖苷中，2、3 和 6 在体外以浓度依赖的方式表现出显著的胰腺脂肪酶抑制活性。在大豆油负荷小鼠中，口服螺旋甾醇 D-2（6）可剂量依赖性地降低血清甘油三酯水平。
