无患子果皮中具有胰脂肪酶抑制活性的齐墩果烷型三萜寡糖苷。
Oleanane-type triterpene oligoglycosides with pancreatic lipase inhibitory activity from the pericarps of Sapindus rarak.
作者信息
Morikawa Toshio, Xie Yuanyuan, Asao Yasunobu, Okamoto Masaki, Yamashita Chihiro, Muraoka Osamu, Matsuda Hisashi, Pongpiriyadacha Yutana, Yuan Dan, Yoshikawa Masayuki
机构信息
Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan.
Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Wenhua Rd., Shenyang 110016, People's Republic of China.
出版信息
Phytochemistry. 2009 Jun;70(9):1166-1172. doi: 10.1016/j.phytochem.2009.06.015. Epub 2009 Jul 31.
The methanolic extract from the pericarps of Sapindus rarak DC. was found to show pancreatic lipase inhibitory activity (IC50=ca. 614 microg/mL). From the extract, oleanane-type triterpene oligoglycosides, rarasaponins I-III (1-3), and raraoside A (4), were isolated together with 13 known saponins and four known sesquiterpene glycosides. Among them, several saponin constituents including rarasaponins I (1, IC50=131microM) and II (2, 172microM), and raraoside A (4, 151microM) inhibited pancreatic lipase activity, which were stronger than that of theasaponin E(1) (270microM).
无患子果皮的甲醇提取物被发现具有胰脂肪酶抑制活性（IC50约为614微克/毫升）。从该提取物中分离出了齐墩果烷型三萜寡糖苷、无患子皂苷I - III（1 - 3）和无患子苷A（4），以及13种已知皂苷和4种已知倍半萜糖苷。其中，包括无患子皂苷I（1，IC50 = 131微摩尔）、II（2，172微摩尔）和无患子苷A（4，151微摩尔）在内的几种皂苷成分抑制了胰脂肪酶的活性，它们比茶皂苷E（1）（270微摩尔）的抑制活性更强。
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