Morikawa Toshio, Xie Yuanyuan, Asao Yasunobu, Okamoto Masaki, Yamashita Chihiro, Muraoka Osamu, Matsuda Hisashi, Pongpiriyadacha Yutana, Yuan Dan, Yoshikawa Masayuki
Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan.
Pharmaceutical Research and Technology Institute, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Wenhua Rd., Shenyang 110016, People's Republic of China.
Phytochemistry. 2009 Jun;70(9):1166-1172. doi: 10.1016/j.phytochem.2009.06.015. Epub 2009 Jul 31.
The methanolic extract from the pericarps of Sapindus rarak DC. was found to show pancreatic lipase inhibitory activity (IC50=ca. 614 microg/mL). From the extract, oleanane-type triterpene oligoglycosides, rarasaponins I-III (1-3), and raraoside A (4), were isolated together with 13 known saponins and four known sesquiterpene glycosides. Among them, several saponin constituents including rarasaponins I (1, IC50=131microM) and II (2, 172microM), and raraoside A (4, 151microM) inhibited pancreatic lipase activity, which were stronger than that of theasaponin E(1) (270microM).
无患子果皮的甲醇提取物被发现具有胰脂肪酶抑制活性（IC50约为614微克/毫升）。从该提取物中分离出了齐墩果烷型三萜寡糖苷、无患子皂苷I - III（1 - 3）和无患子苷A（4），以及13种已知皂苷和4种已知倍半萜糖苷。其中，包括无患子皂苷I（1，IC50 = 131微摩尔）、II（2，172微摩尔）和无患子苷A（4，151微摩尔）在内的几种皂苷成分抑制了胰脂肪酶的活性，它们比茶皂苷E（1）（270微摩尔）的抑制活性更强。
