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SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice.

作者信息

Liu Wen, Wang Meijing, Shen Lihong, Zhu Yuyu, Ma Hongyue, Liu Bo, Ouyang Liang, Guo Wenjie, Xu Qiang, Sun Yang

机构信息

State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing, China.

Jiangsu Key Laboratory of Efficacy and Safety Evaluation of TCM, Nanjing University of Chinese Medicine, Nanjing, China.

出版信息

Signal Transduct Target Ther. 2021 Jan 29;6(1):34. doi: 10.1038/s41392-021-00474-x.

DOI:10.1038/s41392-021-00474-x
PMID:33514686
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7846847/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f553/7846847/69bee5e69429/41392_2021_474_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f553/7846847/69bee5e69429/41392_2021_474_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f553/7846847/69bee5e69429/41392_2021_474_Fig1_HTML.jpg

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SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice.洛伐他汀增强神经元细胞中SHP2介导的线粒体自噬可减轻小鼠帕金森症。
Signal Transduct Target Ther. 2021 Jan 29;6(1):34. doi: 10.1038/s41392-021-00474-x.
2
Correction: SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice.更正：洛伐他汀在神经元细胞中增强的SHP2介导的线粒体自噬减轻小鼠帕金森症。
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Targeting SHP2 as a promising strategy for cancer immunotherapy.以 SHP2 为靶点的癌症免疫治疗策略。
Pharmacol Res. 2020 Feb;152:104595. doi: 10.1016/j.phrs.2019.104595. Epub 2019 Dec 12.
2
Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis.酪氨酸磷酸酶 SHP2 通过依赖于 ANT1 的线粒体稳态负调控 NLRP3 炎性体激活。
Nat Commun. 2017 Dec 18;8(1):2168. doi: 10.1038/s41467-017-02351-0.
3
Defects in trafficking bridge Parkinson's disease pathology and genetics.
将靶向Shp2作为神经退行性疾病的治疗策略。
Transl Psychiatry. 2025 Jan 10;15(1):6. doi: 10.1038/s41398-024-03222-1.
4
Correction: SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice.更正：洛伐他汀在神经元细胞中增强的SHP2介导的线粒体自噬减轻小鼠帕金森症。
Signal Transduct Target Ther. 2024 Dec 26;9(1):370. doi: 10.1038/s41392-024-02103-9.
5
Allosterically activating SHP2 by oleanolic acid inhibits STAT3-Th17 axis for ameliorating colitis.齐墩果酸变构激活SHP2可抑制STAT3-Th17轴以改善结肠炎。
Acta Pharm Sin B. 2024 Jun;14(6):2598-2612. doi: 10.1016/j.apsb.2024.03.017. Epub 2024 Mar 18.
6
Targeting selective autophagy and beyond: From underlying mechanisms to potential therapies.靶向选择性自噬及其相关研究：从潜在机制到潜在治疗方法。
J Adv Res. 2024 Nov;65:297-327. doi: 10.1016/j.jare.2024.05.009. Epub 2024 May 14.
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