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光致变色卷曲螺旋中的构象控制。

Conformational control in a photoswitchable coiled coil.

机构信息

Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.

出版信息

Chem Commun (Camb). 2021 Feb 15;57(12):1442-1445. doi: 10.1039/d0cc08318f.

DOI:10.1039/d0cc08318f
PMID:33514971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7955653/
Abstract

The coiled coil is a common protein tertiary structure intimately involved in mediating protein recognition and function. Due to their structural simplicity, coiled coils have served as attractive scaffolds for the development of functional biomaterials. Herein we describe the design of conformationally-defined coiled coil photoswitches as potential environmentally-sensitive biomaterials.

摘要

螺旋线圈是一种常见的蛋白质三级结构,它在介导蛋白质识别和功能中起着重要作用。由于其结构简单,螺旋线圈已成为功能性生物材料开发的有吸引力的支架。本文描述了设计构象确定的螺旋线圈光开关作为潜在的环境敏感型生物材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d6/7955653/7c3b55930826/nihms-1670809-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d6/7955653/b7eb144c21f2/nihms-1670809-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d6/7955653/40c689a6ff03/nihms-1670809-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d6/7955653/7c3b55930826/nihms-1670809-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d6/7955653/b7eb144c21f2/nihms-1670809-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d6/7955653/40c689a6ff03/nihms-1670809-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87d6/7955653/7c3b55930826/nihms-1670809-f0004.jpg

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本文引用的文献

1
Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics.NEMO 卷曲螺旋模拟物对病毒诱导的 NF-κB 信号的调节。
Nat Commun. 2020 Apr 14;11(1):1786. doi: 10.1038/s41467-020-15576-3.
2
Selective coordination of three transition metal ions within a coiled-coil peptide scaffold.在卷曲螺旋肽支架内对三种过渡金属离子进行选择性配位。
Chem Sci. 2019 Jun 20;10(31):7456-7465. doi: 10.1039/c9sc01165j. eCollection 2019 Aug 21.
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Photoswitchable peptides for spatiotemporal control of biological functions.光致变色肽用于时空控制生物功能。
Chem Commun (Camb). 2019 Aug 22;55(69):10192-10213. doi: 10.1039/c9cc03346g.
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Synthetic Control of Tertiary Helical Structures in Short Peptides.短肽中三级螺旋结构的合成控制。
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Reversible Hierarchical Assembly of Trimeric Coiled-Coil Peptides into Banded Nano- and Microstructures.三聚体卷曲螺旋肽可逆分层组装成带状纳米和微观结构。
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In Vivo Photopharmacology.体内光药理学。
Chem Rev. 2018 Nov 14;118(21):10710-10747. doi: 10.1021/acs.chemrev.8b00037. Epub 2018 Jul 9.
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An Effective Strategy for Stabilizing Minimal Coiled Coil Mimetics.一种稳定最小卷曲螺旋模拟物的有效策略。
J Am Chem Soc. 2015 Sep 16;137(36):11618-21. doi: 10.1021/jacs.5b05525. Epub 2015 Sep 4.
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Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs.由螺旋三级结构基序介导的蛋白质-蛋白质相互作用
J Am Chem Soc. 2015 Sep 16;137(36):11622-30. doi: 10.1021/jacs.5b05527. Epub 2015 Sep 4.
9
Reversible photocontrol of biological systems by the incorporation of molecular photoswitches.通过引入分子光开关对生物系统进行可逆光控。
Chem Rev. 2013 Aug 14;113(8):6114-78. doi: 10.1021/cr300179f. Epub 2013 Apr 25.
10
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