Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 421001, China.
Institute of Pharmacy and Pharmacology, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 421001, China.
Arch Biochem Biophys. 2021 Apr 15;701:108776. doi: 10.1016/j.abb.2021.108776. Epub 2021 Jan 27.
Cancer is a global health issue that origins thousands of deaths annually worldwide. Cyclic peptides are polypeptide chains which are formed by cyclic sequence of amide bonds between proteinogenic or non-proteinogenic amino acids. Numerous evidences indicate that cyclic peptides are implicated with the occurrence and development of cancer. This review presents the current knowledge about the role of cyclic peptides in cancer, such as liver cancer, colorectal cancer, ovarian cancer, breast cancer as well as prostate cancer. Specifically, the precise molecular mechanisms between cyclic peptides and cancer are elaborated. Some cyclic peptides from nature and synthesis prevent the occurrence and development of cancer. However, some other cyclic peptides including endothelin-1, urotensinⅡand melanin-concentrating hormone deteriorate the pathogenesis of cancer. Given the pleiotropic actions of cyclic peptides, the identification and development of cyclic peptides and their derivates as drug may be a potent therapeutic strategy for cancer.
癌症是一个全球性的健康问题，每年在全球范围内导致数千人死亡。环肽是由蛋白质或非蛋白质氨基酸之间的酰胺键形成的环状序列组成的多肽链。大量证据表明，环肽与癌症的发生和发展有关。本文综述了环肽在肝癌、结直肠癌、卵巢癌、乳腺癌和前列腺癌等癌症中的作用的最新知识。具体阐述了环肽与癌症之间的精确分子机制。一些天然和合成的环肽可以预防癌症的发生和发展。然而，一些其他的环肽，包括内皮素-1、尿皮质素Ⅱ和黑色素浓缩激素，会恶化癌症的发病机制。鉴于环肽的多种作用，鉴定和开发环肽及其衍生物作为药物可能是癌症的一种有效治疗策略。
