School of Pharmacy and Bioengineering, Chongqing University of Technology, 405400 Chongqing, China.
Chongqing Key Laboratory of Medicinal Chemistry & Molecular Pharmacology, Chongqing University of Technology, Chongqing 400054, China.
Curr Protein Pept Sci. 2024;25(5):353-375. doi: 10.2174/0113892037272528231030074158.
Cyclic peptides are polypeptide chains formed by cyclic sequences of amide bonds between protein-derived or non-protein-derived amino acids. Compared to linear peptides, cyclic peptides offer several unique advantages, such as increased stability, stronger affinity, improved selectivity, and reduced toxicity. Cyclic peptide has been proved to have a promising application prospect in the medical field. In addition, this paper mainly describes that cyclic peptides play an important role in anti-cancer, anti-inflammatory, anti-virus, treatment of multiple sclerosis and membranous nephropathy through immunomodulation. In order to know more useful information about cyclic peptides in clinical research and drug application, this paper also summarizes cyclic peptides currently in the clinical trial stage and cyclic peptide drugs approved for marketing in the recent five years. Cyclic peptides have many advantages and great potential in treating various diseases, but there are still many challenges to be solved in the development process of cyclic peptides.
环肽是由蛋白质衍生或非蛋白质衍生氨基酸之间的酰胺键形成的环状序列多肽链。与线性肽相比，环肽具有几个独特的优势，如增加的稳定性、更强的亲和力、提高的选择性和降低的毒性。环肽已被证明在医学领域具有广阔的应用前景。此外，本文主要描述了环肽通过免疫调节在抗癌、抗炎、抗病毒、多发性硬化症和膜性肾病的治疗中发挥重要作用。为了了解环肽在临床研究和药物应用中的更多有用信息，本文还总结了目前处于临床试验阶段的环肽和近五年来上市的环肽药物。环肽在治疗各种疾病方面具有许多优势和巨大潜力，但在环肽的开发过程中仍有许多挑战需要解决。
