Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Sumedang 45363, Indonesia.
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Molecules. 2022 Jul 11;27(14):4428. doi: 10.3390/molecules27144428.
Cyclic peptides have been widely reported to have therapeutic abilities in the treatment of cancer. This has been proven through in vitro and in vivo studies against breast, lung, liver, colon, and prostate cancers, among others. The multitude of data available in the literature supports the potential of cyclic peptides as anticancer agents. This review summarizes the findings from previously reported studies and discusses the different cyclic peptide compounds, the sources, and their modes of action as anticancer agents. The prospects and future of cyclic peptides will also be described to give an overview on the direction of cyclic peptide development for clinical applications.
环肽已被广泛报道具有治疗癌症的能力。这已通过针对乳腺癌、肺癌、肝癌、结肠癌和前列腺癌等的体外和体内研究得到证实。文献中提供的大量数据支持环肽作为抗癌药物的潜力。本综述总结了以前报道的研究结果，并讨论了不同的环肽化合物、来源及其作为抗癌药物的作用模式。还将描述环肽的前景和未来，以概述环肽开发用于临床应用的方向。
