Key Laboratory of Animal Virology of Ministry of Agriculture, Institute of Preventive Veterinary Medicine, Department of Veterinary Medicine, Zhejiang University, Hangzhou 310058, China.
Key Laboratory of Animal Virology of Ministry of Agriculture, Institute of Preventive Veterinary Medicine, Department of Veterinary Medicine, Zhejiang University, Hangzhou 310058, China.
Cell Calcium. 2021 Mar;94:102360. doi: 10.1016/j.ceca.2021.102360. Epub 2021 Jan 23.
Ion channels are necessary for correct lysosomal function including degradation of cargoes originating from endocytosis. Almost all enveloped viruses, including coronaviruses (CoVs), enter host cells via endocytosis, and do not escape endosomal compartments into the cytoplasm (via fusion with the endolysosomal membrane) unless the virus-encoded envelope proteins are cleaved by lysosomal proteases. With the ongoing outbreak of severe acute respiratory syndrome (SARS)-CoV-2, endolysosomal two-pore channels represent an exciting and emerging target for antiviral therapies. This review focuses on the latest knowledge of the effects of lysosomal ion channels on the cellular entry and uncoating of enveloped viruses, which may aid in development of novel therapies against emerging infectious diseases such as SARS-CoV-2.
离子通道对于正确的溶酶体功能是必要的，包括对内吞作用起源的货物的降解。几乎所有的包膜病毒，包括冠状病毒（CoVs），都是通过内吞作用进入宿主细胞的，除非病毒编码的包膜蛋白被溶酶体蛋白酶切割，否则它们不会从内体隔室逃到细胞质中（通过与内溶酶体膜融合）。随着严重急性呼吸系统综合症（SARS）-CoV-2 的持续爆发，内溶酶体双孔通道成为抗病毒治疗的一个令人兴奋和新兴的目标。这篇综述重点介绍了溶酶体离子通道对包膜病毒的细胞进入和脱壳的最新知识，这可能有助于开发针对 SARS-CoV-2 等新发传染病的新型疗法。
