The University of Adelaide, Adelaide, Australia; South Australian Health and Medical Research Institute, Adelaide, Australia; Lyell McEwin Hospital, Adelaide, Australia.
The University of Adelaide, Adelaide, Australia; South Australian Health and Medical Research Institute, Adelaide, Australia.
Card Electrophysiol Clin. 2021 Mar;13(1):77-86. doi: 10.1016/j.ccep.2020.11.006. Epub 2021 Jan 8.
Obesity and metabolic syndrome are both associated with atrial fibrillation (AF). Recent research has revealed new insights into the effects of cardiac and noncardiac adipose tissue in mediating these associations. Cardiac adipose tissue, such as epicardial fat, is a powerful predictor of AF and leads to myocardial fatty infiltration and adipokine-induced fibrosis. Increases in noncardiac adipose tissue cause deleterious metabolic, neurohormonal, hemodynamic, and structural changes. Weight loss leads to a regression of adiposity-related fibrosis, structural abnormalities, conduction abnormalities, and reduction in AF burden. As a result, weight loss and risk factor treatment is now an established pillar of AF management.
肥胖和代谢综合征均与心房颤动（AF）有关。最近的研究揭示了心脏和非心脏脂肪组织在介导这些关联中的作用的新见解。心脏脂肪组织，如心外膜脂肪，是 AF 的强有力预测因子，并导致心肌脂肪浸润和脂肪因子诱导的纤维化。非心脏脂肪组织的增加会导致有害的代谢、神经激素、血液动力学和结构变化。减肥可使与肥胖相关的纤维化、结构异常、传导异常和 AF 负荷减少消退。因此，减肥和危险因素治疗现在是 AF 管理的既定支柱。
