血液和唾液 microRNAs 用于口腔鳞状细胞癌的诊断：系统评价和荟萃分析。
Blood and Salivary MicroRNAs for Diagnosis of Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
机构信息
Student, Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu Province, China; and Resident, Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Resident, Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
出版信息
J Oral Maxillofac Surg. 2021 May;79(5):1082.e1-1082.e13. doi: 10.1016/j.joms.2020.12.043. Epub 2020 Dec 30.
PURPOSE
This meta-analysis aimed to compare and evaluate the diagnostic accuracy of blood and salivary microRNAs (miRNAs) in discriminating oral squamous cell carcinoma (OSCC).
METHODS
The PubMed, Embase, Web of Science, and Cochrane Library were searched (updated to February 2020) to identify all articles describing the diagnostic value of blood and salivary miRNAs for OSCC. The pooled parameters were calculated using Revman (v.5.3) and STATA (v.14.0).
RESULTS
Twenty articles involving 1,106 patients and 732 controls were included in this meta-analysis. The pooled sensitivity and specificity of salivary miRNAs were 0.70 (95% CI: 0.63-0.77) and 0.82 (95% CI: 0.72-0.90). For blood miRNAs, they were 0.79 (95% CI: 0.73-0.84) and 0.82 (95% CI: 0.77-0.86). The areas under receiver operating characteristic curve in saliva, blood, and body fluid miRNAs were 0.80 (95% CI: 0.77-0.84), 0.88 (95% CI: 0.84-0.90), and 0.87 (95% CI: 0.84-0.90), respectively.
CONCLUSIONS
The results of this meta-analysis indicate a moderate diagnostic accuracy of blood and salivary miRNAs presented for OSCC. These findings may provide less invasive and relatively reliable diagnostic tools for OSCC detection.
目的
本荟萃分析旨在比较和评估血液和唾液 microRNAs（miRNAs）在鉴别口腔鳞状细胞癌（OSCC）方面的诊断准确性。
方法
检索 PubMed、Embase、Web of Science 和 Cochrane Library（更新至 2020 年 2 月），以确定所有描述血液和唾液 miRNAs 对 OSCC 诊断价值的文章。使用 Revman（v.5.3）和 STATA（v.14.0）计算汇总参数。
结果
本荟萃分析纳入了 20 项涉及 1106 名患者和 732 名对照者的研究。唾液 miRNAs 的汇总敏感性和特异性分别为 0.70（95%CI：0.63-0.77）和 0.82（95%CI：0.72-0.90）。对于血液 miRNAs，它们分别为 0.79（95%CI：0.73-0.84）和 0.82（95%CI：0.77-0.86）。唾液、血液和体液 miRNAs 的受试者工作特征曲线下面积分别为 0.80（95%CI：0.77-0.84）、0.88（95%CI：0.84-0.90）和 0.87（95%CI：0.84-0.90）。
结论
本荟萃分析的结果表明，血液和唾液 miRNAs 对 OSCC 具有中等诊断准确性。这些发现可能为 OSCC 的检测提供侵入性较小且相对可靠的诊断工具。
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