Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.
Zhejiang Cancer Hospital, Hangzhou, 310022, People's Republic of China.
Environ Res. 2021 Apr;195:110776. doi: 10.1016/j.envres.2021.110776. Epub 2021 Jan 28.
To investigate the impact of occupation types on age at natural menopause.
This is a nation-wide cross-sectional study based on 17,948 female workers aged over 40, who come from different industries or organizations. A face-to-face standardized questionnaire was conducted in all participants with the help of occupational hygienists. Occupational titles were coded according to the International Standard Classification of Occupations (2008) (ISCO08). Cox regression model was used to assess the association between each independent occupation and menopausal timing. Models were adjusted for marriage, education, average annual family income, parity, cigarette smoking, alcohol consumption.
Higher risks of earlier age at natural menopause was found among legislators and senior officials (ISCO Minor group:111, HR = 2.328, P < 0.001), among other health associated professionals (ISCO Minor group: 325, HR = 1.477, P = 0.003), the workers involved in mining and mineral processing (ISCO Minor group: 811, HR = 1.515, P = 0.048) and metal processing and finishing (ISCO Minor group: 812, HR = 1.722, P < 0.001). Reduced risks of earlier age at natural menopause, including: finance professionals (ISCO Minor group: 241, HR = 0.751, P = 0.021), manufacturing and construction supervisors (ISCO Minor group: 312, HR = 0.477, P = 0.002), administrative and specialized secretaries (ISCO Minor group: 334, HR = 0.788, P = 0.045), cleaners and helpers (ISCO Minor group: 911, HR = 0.633, P = 0.01).
This is the first study to address the influence of occupation types on reproductive aging, showing some specific occupations could be associated with age at natural menopause. Further investigations are necessary to clarify whether it is chance finding or a true association.
探讨职业类型对自然绝经年龄的影响。
这是一项基于全国范围内不同行业或组织的 17948 名 40 岁以上女性工人的横断面研究。在职业卫生人员的帮助下，所有参与者都进行了面对面的标准化问卷调查。职业名称按照国际职业分类标准（2008 年）（ISCO08）进行编码。Cox 回归模型用于评估每个独立职业与绝经时间之间的关联。模型调整了婚姻、教育、平均家庭年收入、生育次数、吸烟、饮酒。
立法者和高级官员（ISCO 小类：111，HR=2.328，P<0.001）、其他与健康相关的专业人员（ISCO 小类：325，HR=1.477，P=0.003）、从事采矿和矿物加工的工人（ISCO 小类：811，HR=1.515，P=0.048）和金属加工和整理（ISCO 小类：812，HR=1.722，P<0.001）等职业的自然绝经年龄较早的风险较高。自然绝经年龄较早的风险降低，包括：金融专业人员（ISCO 小类：241，HR=0.751，P=0.021）、制造业和建筑主管（ISCO 小类：312，HR=0.477，P=0.002）、行政和专业秘书（ISCO 小类：334，HR=0.788，P=0.045）、清洁工和助手（ISCO 小类：911，HR=0.633，P=0.01）。
这是第一项研究职业类型对生殖衰老影响的研究，表明某些特定职业可能与自然绝经年龄有关。需要进一步研究以明确这是偶然发现还是真正的关联。
