UMRESTTE, Université Claude Bernard Lyon 1, Lyon, France
Radiation: Defense, Health, Environment, INSERM UMR1296, Lyon, France.
Occup Environ Med. 2023 Jul;80(7):407-417. doi: 10.1136/oemed-2022-108601. Epub 2023 May 25.
Testicular germ cell tumours (TGCT) are the most common cancer in men of working age and its incidence has increased notably over the past 40 years. Several occupations have been identified as potentially associated with TGCT risk. The aim of this study was to further explore the relationship between occupations, industries and TGCT risk in men aged 18-45 years.
The TESTIS study is a multicenter case-control study conducted between January 2015 and April 2018 in 20 of 23 university hospital centers in metropolitan France. A total of 454 TGCT cases and 670 controls were included. Full job histories were collected. Occupations were coded according to the International Standard Classification of Occupation 1968 version (ISCO-1968) and industry according to the 1999 version of Nomenclature d'Activités Française (NAF-1999). For each job held, ORs and 95% CIs were estimated using conditional logistic regression.
A positive association was observed between TGCT and occupation as agricultural, animal husbandry worker (ISCO: 6-2; OR 1.71; 95% CI (1.02 to 2.82)), as well as salesman (ISCO: 4-51; OR 1.84; 95% CI (1.20 to 2.82)). An increased risk was further observed among electrical fitters and related, electrical and electronics workers employed for 2 years or more (ISCO: 8-5; OR 1.83; 95% CI (1.01 to 3.32)). Analyses by industry supported these findings.
Our findings suggest that agricultural, electrical and electronics workers, and salesmen workers experience an increased risk of TGCT. Further research is needed to identify the agents or chemicals in these high-risk occupations which are relevant in the TGCT development.
NCT02109926.
睾丸生殖细胞肿瘤（TGCT）是工作年龄段男性中最常见的癌症，在过去的 40 年中，其发病率显著增加。已经确定了一些职业可能与 TGCT 风险相关。本研究旨在进一步探讨 18-45 岁男性的职业、行业与 TGCT 风险之间的关系。
TESTIS 研究是一项多中心病例对照研究，于 2015 年 1 月至 2018 年 4 月在法国 23 个大都市地区的 20 个大学医院中心进行。共纳入 454 例 TGCT 病例和 670 例对照。收集了完整的工作经历。职业按照 1968 年版国际职业分类（ISCO-1968）和 1999 年版法国活动命名（NAF-1999）进行编码。对于每个工作岗位，使用条件逻辑回归估计 OR 和 95%置信区间（CI）。
TGCT 与农业、畜牧业工人（ISCO：6-2；OR 1.71；95%CI（1.02 至 2.82））以及销售人员（ISCO：4-51；OR 1.84；95%CI（1.20 至 2.82））之间存在正相关。还观察到电气装配工和相关的电气和电子工人从事 2 年或以上工作的风险增加（ISCO：8-5；OR 1.83；95%CI（1.01 至 3.32））。按行业进行的分析支持了这些发现。
我们的研究结果表明，农业、电气和电子工人以及销售人员的 TGCT 风险增加。需要进一步研究以确定这些高风险职业中与 TGCT 发展相关的代理或化学物质。
NCT02109926。
