Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, Italy.
The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UK.
Exp Gerontol. 2021 May;147:111262. doi: 10.1016/j.exger.2021.111262. Epub 2021 Jan 29.
Sarcopenia is a common condition in older people and increasing evidence suggests that it can be considered as a potential risk factor for falls and fractures. However, no studies on this topic from low- and middle-income countries (LMICs) are available. Thus, we assessed this association among older adults from five LMICs (China, India, Ghana, Mexico, and Russia). Community-based, nationally representative, cross-sectional data of the Study on Global Aging and Adult Health were analyzed. Sarcopenia was defined as the presence of low skeletal muscle mass based on indirect population formula, and either slow gait or low handgrip strength. The presence of fall-related injury was ascertained through self-reported information. Multivariable logistic regression analysis and meta-analysis were conducted. The sample consisted of 13,101 individuals aged ≥65 years (mean (SD) age 72.6 (11.3) years; 45% males). The prevalence of fall-related injury was higher among those with sarcopenia than in those without this condition (e.g., Mexico 9.8% vs. 2.7%). Adjusted analyses showed that sarcopenia was associated with a 1.85 (95%CI = 1.24-2.77) times higher odds for fall-related injury, with a low level of between-country heterogeneity. Future studies of longitudinal design may shed light on whether sarcopenia in LMICs may be considered as a risk factor for falls.
肌少症是老年人中常见的病症，越来越多的证据表明，它可能被视为跌倒和骨折的潜在风险因素。然而，来自中低收入国家（LMICs）的关于这个主题的研究尚不存在。因此，我们评估了来自五个 LMICs（中国、印度、加纳、墨西哥和俄罗斯）的老年人中这种关联。对全球老龄化和成人健康研究的基于社区、具有国家代表性的横断面数据进行了分析。肌少症的定义是基于间接人群公式存在低骨骼肌量，以及步态缓慢或手握力低。通过自我报告的信息确定与跌倒相关的损伤的存在。进行了多变量逻辑回归分析和荟萃分析。样本包括 13101 名年龄≥65 岁的个体（平均（SD）年龄 72.6（11.3）岁；45%为男性）。与无肌少症者相比，有肌少症者跌倒相关损伤的发生率更高（例如，墨西哥为 9.8%比 2.7%）。调整后的分析表明，肌少症与跌倒相关损伤的几率增加 1.85 倍（95%CI=1.24-2.77），且国家间异质性较低。未来的纵向设计研究可能会阐明肌少症在 LMICs 中是否可以被视为跌倒的风险因素。
