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COVID-19 致死病例中的肝脏血管病和肝脏再生反应。

Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19.

机构信息

Department of Cell Biology, Faculty of Biology, University of Bielefeld, Bielefeld, Germany.

Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

出版信息

Clin Gastroenterol Hepatol. 2021 Aug;19(8):1726-1729.e3. doi: 10.1016/j.cgh.2021.01.044. Epub 2021 Jan 29.

DOI:10.1016/j.cgh.2021.01.044
PMID:33516952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7844358/
Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects the nasopharynx and lungs and causes coronavirus disease-2019 (COVID-19). It may impact the heart, brain, kidney, and liver. Although functional impairment of the liver has been correlated with worse clinical outcomes, little is known about the pathophysiology of hepatic injury and repair in COVID-19. Histologic evaluation has been limited to small numbers of COVID-19 cases with no control subjects and demonstrated largely heterogeneous patterns of pathology..

摘要

严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）感染鼻咽部和肺部，引起 2019 冠状病毒病（COVID-19）。它可能影响心脏、大脑、肾脏和肝脏。虽然肝脏功能障碍与更差的临床结局相关，但 COVID-19 中肝损伤和修复的病理生理学机制知之甚少。组织学评估仅限于少数 COVID-19 病例，没有对照，显示出病理表现很大的异质性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95de/7844358/65cd821f8003/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95de/7844358/65cd821f8003/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95de/7844358/65cd821f8003/gr1_lrg.jpg

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