Department of Natural Product Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, People's Republic of China.
Department of Natural Product Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
Bioorg Chem. 2021 Mar;108:104641. doi: 10.1016/j.bioorg.2021.104641. Epub 2021 Jan 12.
LC-MS guided chemical investigation of the periploside-rich extract of the root barks of Periploca sepium afforded six new minor pregnane glycosides, named periplosides A1-A6 (1-6). Their structures were characterized on the basis of extensive spectroscopic analysis. Compounds 1-6 were evaluated for their inhibitory activities against the proliferation of T and B lymphocytes in vitro, among them, compound 5 exhibited significant inhibitory activities and the most favorite selective index (SI) values against the proliferation of T lymphocyte (IC = 0.30 μM, SI = 176) and B lymphocyte (IC = 0.55 μM, SI = 97).
LC-MS 引导的对杠柳根皮中富含杠柳苷的提取物的化学成分研究，得到了六个新的孕烷糖苷类化合物，命名为杠柳苷 A1-A6（1-6）。它们的结构是基于广泛的光谱分析来确定的。对化合物 1-6 进行了体外抑制 T 和 B 淋巴细胞增殖活性的评价，其中，化合物 5 对 T 淋巴细胞（IC=0.30μM，SI=176）和 B 淋巴细胞（IC=0.55μM，SI=97）的增殖具有显著的抑制活性和最理想的选择性指数（SI）值。
