Department of Surgery, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan;
Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Anticancer Res. 2021 Feb;41(2):1069-1076. doi: 10.21873/anticanres.14864.
BACKGROUND/AIM: Emergency surgery for colorectal cancer (CRC) is a high-risk procedure with high morbidity and mortality rates, especially for older patients. The relationship between patient age status and long-term outcomes is unclear. We hypothesize that patient age might be associated with long-term outcomes in patients with CRC who undergo emergency surgery.
Utilizing a database of CRC patients who received emergency surgery, we examined the prognostic association of patient age.
The ≥80-years group was significantly associated with American Society of Anesthesiologists (ASA) physical status, bowel obstruction, N stage, shorter operating time, and less adjuvant chemotherapy (all p<0.03); and also, with shorter recurrence-free survival [multivariable hazard ratio, 2.79; 95% confidence interval, 1.13-7.21; p=0.026]. ASA status and adjuvant chemotherapy were significantly associated with recurrence-free survival (all p<0.03).
Advanced age is associated with shorter recurrence-free survival in CRC patients who undergo emergency surgery.
背景/目的：结直肠癌（CRC）的急诊手术是一种高风险的手术，其发病率和死亡率都很高，尤其是对于老年患者而言。患者年龄状况与长期预后之间的关系尚不清楚。我们假设，对于接受急诊手术的 CRC 患者，患者的年龄可能与长期预后相关。
利用接受急诊手术的 CRC 患者的数据库，我们研究了患者年龄与预后的关系。
≥80 岁组与美国麻醉医师协会（ASA）身体状况、肠梗阻、N 分期、手术时间更短和辅助化疗更少（均 p<0.03）显著相关；同时，与无复发生存率较短显著相关[多变量风险比，2.79；95%置信区间，1.13-7.21；p=0.026]。ASA 状态和辅助化疗与无复发生存率显著相关（均 p<0.03）。
对于接受急诊手术的 CRC 患者，年龄较大与无复发生存率较短相关。
