多囊卵巢综合征：青春期的发生机制。
Polycystic Ovary Syndrome: Ontogeny in Adolescence.
机构信息
Center for Research in Reproduction, University of Virginia School of Medicine, OMS Suhling Building, Room 6921, Hospital Drive, Charlottesville, VA 22908, USA; Department of Pediatrics, Division of Endocrinology and Metabolism, University of Virginia School of Medicine, University of Virginia Health, Box 800386, Charlottesville, VA 22908, USA.
Center for Research in Reproduction, University of Virginia School of Medicine, OMS Suhling Building, Room 6921, Hospital Drive, Charlottesville, VA 22908, USA; Department of Medicine, Division of Endocrinology and Metabolism, University of Virginia School of Medicine, University of Virginia Health, Box 801406, Charlottesville, VA 22908, USA.
出版信息
Endocrinol Metab Clin North Am. 2021 Mar;50(1):25-42. doi: 10.1016/j.ecl.2020.10.003. Epub 2021 Jan 11.
The pathophysiology of symptomatic polycystic ovary syndrome (PCOS) often unfolds across puberty, but the ontogeny of PCOS is difficult to study because, in general, its pathophysiology is well entrenched before the diagnosis can be confirmed. However, the study of high-risk groups (daughters of women with PCOS, girls with premature pubarche, and girls with obesity) can offer insight in this regard. Available data support the hypothesis that the pubertal development of PCOS involves various combinations of genetic predisposition, intrauterine programming, hyperinsulinism, and numerous other abnormalities that provoke reproductive symptoms (eg, hyperandrogenism, ovulatory dysfunction) in response to the pubertal increase in gonadotropin secretion.
多囊卵巢综合征（PCOS）的症状的病理生理学通常在青春期展开，但 PCOS 的发生机制很难研究，因为其病理生理学通常在可以确诊之前就已经根深蒂固了。然而，对高危人群（患有 PCOS 的女性的女儿、性早熟的女孩和肥胖的女孩）的研究可以提供这方面的见解。现有数据支持以下假设：PCOS 的青春期发育涉及各种遗传易感性、宫内编程、高胰岛素血症以及其他许多异常的组合，这些异常会在青春期促性腺激素分泌增加时引发生殖症状（如高雄激素血症、排卵功能障碍）。
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