Ibáñez L, de Zegher F, Potau N
Adolescent and Endocrine Unit, Hospital Universitario Materno-Infantil Vall d'Hebron, Barcelona, Spain.
J Endocrinol Invest. 1998 Oct;21(9):558-66. doi: 10.1007/BF03350781.
Adolescent girls with a history of premature pubarche have an increased incidence of functional ovarian hyperandrogenism [a form of polycystic ovary syndrome (PCOS)] at adolescence, which is usually associated with hyperinsulinemia and dyslipemia. The hyperinsulinemia and lipid disturbances can often be detected in the prepubertal period and throughout puberty, and are associated with an exaggerated ovarian androgen synthesis. Birthweight SD scores are lower in premature pubarche girls than in control girls, and particularly so in those girls who show hyperinsulinemia and subsequently develop ovarian hyperandrogenism. Therefore, although the mechanisms interlinking the triad of premature pubarche, hyperinsulinism and ovarian hyperandrogenism remain enigmatic, these data indicate that the triad may result, at least in part, from a common early origin, rather than from a direct interrelationship later in life.
有青春期前阴毛早现病史的青春期女孩，在青春期发生功能性卵巢雄激素过多症（多囊卵巢综合征的一种形式）的几率增加，这通常与高胰岛素血症和血脂异常有关。高胰岛素血症和脂质紊乱在青春期前及整个青春期常可检测到，且与卵巢雄激素合成过度有关。阴毛早现女孩的出生体重标准差得分低于对照女孩，在那些出现高胰岛素血症并随后发生卵巢雄激素过多症的女孩中尤其如此。因此，尽管将阴毛早现、高胰岛素血症和卵巢雄激素过多症这三者联系起来的机制仍不清楚，但这些数据表明，这三者至少部分是由共同的早期起源导致的，而非源于生命后期的直接相互关系。
