Wang Zichao, Liu Tao, Li Jiameng, Gu Qing
School of Public Health, Tianjin Medical University, China.
Tianjin Centre for Disease Control and Prevention, China.
Jpn J Infect Dis. 2021 Sep 22;74(5):437-442. doi: 10.7883/yoken.JJID.2020.983. Epub 2021 Jan 29.
Hand, foot, and mouth disease (HFMD) due to Coxsackievirus A6 (CV-A6) has demonstrated an increasing trend in China. Our study aimed to explore the risk factors of HFMD cases infected with CV-A6 among children under 6 years of age in Tianjin, China. The non-matching case-control study included cases which were HFMD patients infected with CV-A6 while controls were HFMD patients infected with other enteroviruses. Multivariate logistic regression analysis was used to explore the risk factors of HFMD cases infected with CV-A6. A total of 1,264 eligible cases were included in our study, including 589 cases and 675 controls. Our study suggests that CV-A6 infected HFMD patients were more likely to present with fever and rash on limbs, and home-care children and children having a history of contacting HFMD patient had a high risk of infection with CV-A6, while toy sterilization regularly at home and parents' hand-washing habits after toilet use were protective factors for children against CV-A6 infection.
由柯萨奇病毒A6（CV-A6）引起的手足口病（HFMD）在中国呈上升趋势。我们的研究旨在探讨中国天津6岁以下儿童感染CV-A6的手足口病病例的危险因素。非匹配病例对照研究中，病例为感染CV-A6的手足口病患者，对照为感染其他肠道病毒的手足口病患者。采用多因素logistic回归分析探讨感染CV-A6的手足口病病例的危险因素。本研究共纳入1264例符合条件的病例，其中病例589例，对照675例。我们的研究表明，感染CV-A6的手足口病患者更易出现发热和四肢皮疹，居家护理儿童以及有接触手足口病患者病史的儿童感染CV-A6的风险较高，而在家定期对玩具进行消毒以及家长便后洗手习惯是儿童预防CV-A6感染的保护因素。
