Khan Mohsin Ali, Khan Zaw Ali, Charles Mark, Pratap Pushpendra, Naeem Abdul, Siddiqui Zainab, Naqvi Nigar, Srivastava Shikha
Reseach & Development Department, Era's Lucknow Medical College & Hospital, Lucknow, Uttar Pradesh, India.
Metabolic Research Unit, Era's Lucknow Medical College & Hospital, Lucknow, Uttar Pradesh, India.
J Inflamm Res. 2021 Jan 22;14:175-189. doi: 10.2147/JIR.S271292. eCollection 2021.
Mucus is an integral part of the respiratory physiology. It protects the respiratory tract by acting as a physical barrier against inhaled particles and microbes. Excessive inflammation in conditions such as COVID-19 can result in over-production of mucus which obstructs the airway. Build-up of mucus can also contribute to recurrent airway infection, causing further obstruction. This article summarizes the current understanding and knowledge of respiratory mucus production and proposes the role of cytokine storm in inducing sudden mucus hypersecretion in COVID-19. Based on these cascades, the active constituents that inhibit or activate several potential targets are outlined for further research. These may be explored for the discovery and design of drugs to combat cytokine storm and its ensuing complications.
黏液是呼吸生理的一个组成部分。它通过作为抵御吸入颗粒和微生物的物理屏障来保护呼吸道。在新冠肺炎等病症中，过度炎症会导致黏液过度产生，从而阻塞气道。黏液的积聚还会导致反复的气道感染，造成进一步阻塞。本文总结了目前对呼吸道黏液产生的理解和认识，并提出了细胞因子风暴在新冠肺炎中诱导突然黏液分泌过多的作用。基于这些级联反应，概述了抑制或激活几个潜在靶点的活性成分，以供进一步研究。这些成分可用于探索发现和设计对抗细胞因子风暴及其后续并发症的药物。
