新冠肺炎肺炎 11 例危重症患者细胞因子释放综合征的定义和风险：疾病特征分析。
Definition and Risks of Cytokine Release Syndrome in 11 Critically Ill COVID-19 Patients With Pneumonia: Analysis of Disease Characteristics.
机构信息
Guangzhou Respiratory Health Research Institute, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Diseases, Guangdong, China.
Department of Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangdong, China.
出版信息
J Infect Dis. 2020 Oct 1;222(9):1444-1451. doi: 10.1093/infdis/jiaa387.
Abstract
Corona virus disease 2019 (COVID-19) patients with severe immune abnormalities are at risk of cytokine release syndrome (CRS). The definition, prevention, and treatment of symptoms of CRS in critically ill patients with COVID-19 are important problems. We report a single-center case series of 11 COVID-19 patients with acute respiratory distress syndrome from The First Affiliated Hospital of Guangzhou Medical University in China from 26 January 2020 to 18 February 2020. The termination date of follow-up was 19 February 2020. Eight patients were determined to have characteristics of CRS, including pulmonary inflammation, fever, and dysfunction of nonpulmonary organs. An increase in interleukin-6 in peripheral blood was the highest risk factor and an early indicator of CRS in COVID-19.
摘要
2019 年冠状病毒病（COVID-19）患者若伴有严重免疫异常，则有发生细胞因子释放综合征（CRS）的风险。因此，对于 COVID-19 重症患者，CRS 症状的定义、预防和治疗是重要问题。我们报道了中国广州医科大学附属第一医院 2020 年 1 月 26 日至 2 月 18 日期间收治的 11 例急性呼吸窘迫综合征 COVID-19 患者的单中心病例系列研究。随访截止日期为 2020 年 2 月 19 日。8 例患者具有 CRS 的特征，包括肺部炎症、发热和非肺部器官功能障碍。外周血白细胞介素 6 升高是 CRS 的最高风险因素和 COVID-19 的早期指标。
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