Tyagi Rahul, Arvind Harshita, Goyal Manoj, Anand Akshay, Mohanty Manju
Neuroscience Research Lab, Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Front Psychol. 2021 Jan 15;11:613242. doi: 10.3389/fpsyg.2020.613242. eCollection 2020.
Neuropsychological profile of Indian Duchenne muscular dystrophy (DMD) subjects remains unidentified and needs to be evaluated.
A total of 69 DMD and 66 controls were subjected to detailed intelligence and neuropsychological assessment. The factor indexes were derived from various components of Malin's Intelligence Scale for Indian Children (MISIC) and Rey Auditory Verbal Learning Test (RAVLT).
Poor verbal and visual memory profiles were demonstrated by DMDs, which include RAVLT-immediate recall (IR) ( = 0.042), RAVLT-delayed recall (DR) ( = 0.009), Rey-Osterrieth complex figure test (RCFT)-IR ( = 0.001), and RCFT-DR ( = 0.001). RAVLT-memory efficiency index demonstrated poor verbal memory efficiency ( = 0.008). Significant differences in the functioning of working memory axis [RAVLT T1 ( = 0.015), recency T1 ( = 0.004), Digit Span Backward ( = 0.103)] were observed along with reduced performance in visuomotor coordination, visuospatial, and visual recognition abilities. Block designing efficiency index and attention fraction showed a normal performance in DMD kids.
Working memory deficits were found to be the crucial element of cognitive functioning in DMD cases. Working memory interventions may be beneficial to improve the neuropsychological profile in DMD.
印度杜氏肌营养不良症（DMD）患者的神经心理学特征尚未明确，需要进行评估。
对69名DMD患者和66名对照者进行了详细的智力和神经心理学评估。因子指数来自于《印度儿童马林智力量表》（MISIC）和雷伊听觉词语学习测验（RAVLT）的各个组成部分。
DMD患者表现出较差的言语和视觉记忆特征，包括RAVLT即时回忆（IR）（=0.042）、RAVLT延迟回忆（DR）（=0.009）、雷伊-奥斯特里赫复杂图形测验（RCFT）-IR（=0.001）和RCFT-DR（=0.001）。RAVLT记忆效率指数显示言语记忆效率较差（=0.008）。观察到工作记忆轴功能存在显著差异[RAVLT T1（=0.015）、近因效应T1（=0.004）、数字广度倒背（=0.103）]，同时视运动协调、视觉空间和视觉识别能力表现下降。积木设计效率指数和注意力分数在DMD患儿中表现正常。
发现工作记忆缺陷是DMD病例认知功能的关键因素。工作记忆干预可能有助于改善DMD患者的神经心理学特征。
