Zhang Wei, Li Lijuan, Zhang Xuelian, Fang Hongshu, Chen Huajian, Rong Changxian
Department of Clinical Laboratory, The Fourth People's Hospital of Chongqing, Chongqing 400014, China.
Department of Gynecology, The Fourth People's Hospital of Chongqing, Chongqing 400014, China.
Can J Infect Dis Med Microbiol. 2021 Jan 13;2021:8842267. doi: 10.1155/2021/8842267. eCollection 2021.
The aim of this study was to estimate the and infection prevalence and antibiotic resistance levels in gynecological outpatients. Clinical characteristics and laboratory data of gynecological outpatients of the Fourth People's Hospital of Chongqing from 2015 to 2018 were retrospectively analyzed. Antibiotic resistance levels in and were defined by a commercial kit for antibiotic susceptibility testing. Univariate analysis and multivariate logistic regression analysis were performed to evaluate risk factors associated with isolation. Comparisons of yearly distributions and resistance rates were assessed by chi-square tests. Fifty-six percent of gynecological outpatients were positive for , and 11.02% were positive for . In the univariate analysis, women aged 30-39 years or with a history of pregnancy or gynecological diseases had an increased risk for isolation, while women who were postmenopausal or had an education level of undergraduate degree or above had a decreased risk of isolation. In the multivariate logistic regression model, an independent risk factor for isolation was a history of gynecological diseases, while a bachelor's degree, master's degree, or above were protective factors against isolation. There were distinctly gradual increases in the positivity rates of and from 2015 to 2018 and an overall increasing trend of resistance to ten antibiotics among and . The top three antibiotics associated with resistance were ofloxacin, sparfloxacin, and levofloxacin. Doxycycline, josamycin, and minocycline were preferred because they had the lowest levels of resistance. Increases in the prevalence of infection and antibiotic resistance in and were observed from 2015 to 2018, clearly confirming the necessity to monitor the standardized administration of antibiotics.
本研究旨在评估妇科门诊患者中[具体病原体1]和[具体病原体2]的感染率及抗生素耐药水平。回顾性分析了重庆市第四人民医院2015年至2018年妇科门诊患者的临床特征和实验室数据。[具体病原体1]和[具体病原体2]的抗生素耐药水平通过商用[抗生素药敏试验试剂盒名称]试剂盒进行测定。采用单因素分析和多因素逻辑回归分析来评估与[具体病原体1]分离相关的危险因素。通过卡方检验评估年度分布和耐药率的比较。56%的妇科门诊患者[具体病原体1]检测呈阳性，11.02%的患者[具体病原体2]检测呈阳性。在单因素分析中，年龄在30 - 39岁、有妊娠史或妇科疾病史的女性[具体病原体1]分离风险增加，而绝经后女性或本科及以上学历女性[具体病原体1]分离风险降低。在多因素逻辑回归模型中，妇科疾病史是[具体病原体1]分离的独立危险因素，而学士学位、硕士学位及以上是预防[具体病原体1]分离的保护因素。2015年至2018年，[具体病原体1]和[具体病原体2]的阳性率呈明显逐渐上升趋势，且对十种抗生素的耐药总体呈上升趋势。与耐药相关的前三种抗生素是氧氟沙星、司帕沙星和左氧氟沙星。强力霉素、交沙霉素和米诺环素耐药水平最低，为首选药物。2015年至2018年观察到[具体病原体1]和[具体病原体2]感染率及抗生素耐药性增加，明确证实了监测抗生素规范使用的必要性。
