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[膝关节孤立性结核性关节炎一例报告:青少年中的疑难诊断]

[Report of a case of isolated tuberculous arthritis of the knee: a difficult diagnosis in adolescents].

作者信息

Benchanna Rachid, Benjelloune Amine, Abdelafatah Zidane, Arsalane Adil, Janah Hicham, Oujaber Jamal, Boui Meriem, Samri Ikram, Bouchentouf Rachid

机构信息

Service de Pneumologie de l´Hôpital Militaire Avicenne Marrakech, Marrakech, Maroc.

Service de Chirurgie Thoracique de l´Hôpital Militaire Avicenne Marrakech, Marrakech, Maroc.

出版信息

Pan Afr Med J. 2020 Nov 6;37:225. doi: 10.11604/pamj.2020.37.225.26470. eCollection 2020.

DOI:10.11604/pamj.2020.37.225.26470
PMID:33520064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7821801/
Abstract

Tuberculosis is a major global public health problem. Osteoarticular tuberculosis is very rare. In half of the cases it affects the vertebrae. Symptoms are insidious over a prolonged period and isolation of the pathogen is difficult, mostly leading to difficult and delayed diagnosis. We here report a new case of tuberculous arthritis of the knee in a teenager in whom the mean time between symtom onset and definitive diagnosis based on the detection of Mycobacterium tuberculosis genome by Xpert MTB/RIF test was eight months. This study emphasizes the importance of bacteriological sampling and diagnostic methods by molecular assay in early and definitive diagnosis of tuberculous arthritis.

摘要

结核病是一个重大的全球公共卫生问题。骨关节炎型结核病非常罕见。其中一半的病例会影响脊椎。症状在很长一段时间内隐匿出现,且病原体分离困难,大多导致诊断困难和延迟。我们在此报告一例青少年膝关节结核性关节炎的新病例,该病例从症状出现到通过Xpert MTB/RIF检测结核分枝杆菌基因组确诊的平均时间为8个月。本研究强调了细菌学采样和分子检测诊断方法在结核性关节炎早期和明确诊断中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b97/7821801/cbb99b09649f/PAMJ-37-225-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b97/7821801/18d0dd000681/PAMJ-37-225-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b97/7821801/cbb99b09649f/PAMJ-37-225-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b97/7821801/18d0dd000681/PAMJ-37-225-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b97/7821801/cbb99b09649f/PAMJ-37-225-g002.jpg

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1
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本文引用的文献

1
Tuberculosis: Diagnostic Challenges in Rural Africa.结核病:非洲农村地区的诊断挑战
Praxis (Bern 1994). 2019 Nov;108(15):991-996. doi: 10.1024/1661-8157/a003355.
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Tuberculosis control in people living with HIV/AIDS.艾滋病毒/艾滋病感染者的结核病控制
Rev Lat Am Enfermagem. 2016 Sep 9;24(0):e2798. doi: 10.1590/1518-8345.1187.2798.
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[Bone tuberculosis: when consider this diagnosis?].[骨结核:何时考虑此诊断?]
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Tuberculosis of patella.髌骨结核
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