Ratre Yashwant Kumar, Kahar Namrata, Bhaskar L V K S, Bhattacharya Antaripa, Verma Henu Kumar
Department of Biotechnology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India.
Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India.
3 Biotech. 2021 Feb;11(2):94. doi: 10.1007/s13205-021-02657-3. Epub 2021 Jan 25.
Novel coronavirus disease 2019 (COVID-19) is a positive-sense single-stranded RNA virus which belongs to the Coronaviridae family. COVID-19 outbreak became evident after the severe acute respiratory syndrome coronavirus and the Middle East respiratory syndrome coronavirus in the twenty-first century as the start of the third deadly coronavirus. Currently, research is at an early stage, and the exact etiological dimensions of COVID-19 are unknown. Several candidate drugs and plasma therapy have been considered and evaluated for the treatment of severe COVID-19 patients. These include clinically available drugs such as chloroquine, hydroxychloroquine, and lopinavir/ritonavir. However, understanding the pathogenic mechanisms of this virus is critical for predicting interaction with humans. Based on recent evidence, we have summarized the current virus biology in terms of the possible understanding of the various pathophysiologies, molecular mechanisms, recent efficient diagnostics, and therapeutic approaches to control the disease. In addition, we briefly reviewed the biochemistry of leading candidates for novel therapies and their current status in clinical trials. As information from COVID-19 is evolving rapidly, this review will help the researcher to consider new insights and potential therapeutic approaches based on up-to-date knowledge. Finally, this review illustrates a list of alternative therapeutic solutions for a viral infection.
2019年新型冠状病毒病（COVID-19）是一种正链单股RNA病毒，属于冠状病毒科。2019年新型冠状病毒病疫情在严重急性呼吸综合征冠状病毒和中东呼吸综合征冠状病毒之后变得明显，成为21世纪第三种致命冠状病毒的开端。目前，研究尚处于早期阶段，COVID-19的确切病因范围尚不清楚。已经对几种候选药物和血浆疗法进行了考虑和评估，用于治疗重症COVID-19患者。这些药物包括临床上可用的药物，如氯喹、羟氯喹和洛匹那韦/利托那韦。然而，了解这种病毒的致病机制对于预测其与人类的相互作用至关重要。基于最近的证据，我们从对各种病理生理学、分子机制、最新有效诊断方法以及控制该疾病的治疗方法的可能理解方面总结了当前的病毒生物学。此外，我们简要回顾了新型疗法主要候选药物的生物化学及其在临床试验中的现状。由于来自COVID-19的信息迅速演变，本综述将帮助研究人员基于最新知识考虑新的见解和潜在的治疗方法。最后，本综述列出了一系列针对病毒感染的替代治疗方案。
