Gumber Khushbu
Department of Chemistry, Chandigarh University, Gharuan, India.
Department of Chemistry, Punjab Agricultural University, Ludhiana, India.
Mater Today Proc. 2021;45:3328-3335. doi: 10.1016/j.matpr.2020.12.649. Epub 2021 Jan 13.
Human Coronavirus (COVID-19) is a worldwide pandemic of 2019-20 that was emerged in China in December 2019. More than 37,000deaths with7, 84, 440confirmed cases has been reported from around 200 different countries has been reported till now and the number is increasing every second. The spread is said to be through human to human transmission via close contact or respiratory droplets produced when people cough or sneeze. No treatment for the illness has been approved yet. The urgent need is to find solution to this growing problem that has affected the whole mankind. World Health Organisation (WHO) as well as US Food and Drug Administration (FDA) are continuously working to find the solution. In the same line they have proposed many potent drugs that may have efficiency against the newly emerged viral infection. To support the efforts the present study is designed to carry out the analysis Docking studies of around 16drugs recently recommended by US FDA by observing the interaction of test molecules with SARS proteinase.
人类冠状病毒（COVID-19）是2019 - 2020年的全球大流行病，于2019年12月在中国出现。截至目前，已报告来自约200个不同国家的超过37000例死亡病例和784440例确诊病例，且数字每秒都在增加。据说传播途径是通过人与人之间的密切接触或人们咳嗽或打喷嚏时产生的呼吸道飞沫。目前尚无针对该疾病的批准治疗方法。迫切需要找到解决这个影响全人类的日益严重问题的办法。世界卫生组织（WHO）以及美国食品药品监督管理局（FDA）正在持续努力寻找解决方案。同样，他们已经提出了许多可能对新出现的病毒感染有效的强效药物。为支持这些努力，本研究旨在通过观察测试分子与SARS蛋白酶的相互作用，对美国FDA最近推荐的约16种药物进行对接研究分析。
