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肠道微生物群:内分泌疾病精准医学的一个视角

Gut microbiota: a perspective of precision medicine in endocrine disorders.

作者信息

Shirvani Rad Salman, Nikkhah Amirabbas, Orvatinia Mohammadmahdi, Ejtahed Hanieh-Sadat, Sarhangi Negar, Jamaldini Seyed Hamid, Khodayari Nazli, Aghaei Meybodi Hamid Reza, Hasanzad Mandana

机构信息

Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Diabetes Metab Disord. 2020 Aug 12;19(2):1827-1834. doi: 10.1007/s40200-020-00593-2. eCollection 2020 Dec.

Abstract

Gut microbiota composition is unique in every individual, it impacts on organ functions that produce hormones. Gut microbiota composition balance is directly related to our general health status. This continual interaction between gut microbiota and endocrine organs sometimes can be considered as the etiology of diseases such as type 2 diabetes mellitus (T2DM), obesity, osteoporosis, polycystic ovary syndrome (PCOS), and thyroid diseases. Microbiota is introduced for a total collection of microbial organisms in our bodies and microbiome referred for their genome and their collective functions. Near 100 trillion microorganisms live in our body and almost all of them occupy the human gut gastrointestinal tract. Precision medicine can play a crucial role in health maintenance by affecting gut microbiota composition in every individual. It can also develop special treatments specifically for every individual. In this review, we addressed any correlation between gut microbiota and endocrine disorders including T2DM, obesity, PCOS, thyroid disorders and osteoporosis.

摘要

每个人的肠道微生物群组成都是独特的,它会影响产生激素的器官功能。肠道微生物群组成的平衡与我们的总体健康状况直接相关。肠道微生物群与内分泌器官之间的这种持续相互作用有时可被视为2型糖尿病(T2DM)、肥胖症、骨质疏松症、多囊卵巢综合征(PCOS)和甲状腺疾病等疾病的病因。微生物群是指我们体内微生物有机体的总体集合,而微生物组则指它们的基因组及其集体功能。我们体内生活着近100万亿个微生物,几乎所有这些微生物都存在于人体胃肠道中。精准医学可以通过影响每个人的肠道微生物群组成在健康维护中发挥关键作用。它还可以为每个人开发专门的治疗方法。在这篇综述中,我们探讨了肠道微生物群与包括T2DM、肥胖症PCOS甲状腺疾病和骨质疏松症在内的内分泌紊乱之间的任何相关性。

相似文献

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Gut microbiota: a perspective of precision medicine in endocrine disorders.肠道微生物群:内分泌疾病精准医学的一个视角
J Diabetes Metab Disord. 2020 Aug 12;19(2):1827-1834. doi: 10.1007/s40200-020-00593-2. eCollection 2020 Dec.
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Profile of the gut microbiota of adults with obesity: a systematic review.肥胖成人肠道微生物组特征:系统评价。
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A New Approach to Polycystic Ovary Syndrome: The Gut Microbiota.多囊卵巢综合征的新方法:肠道微生物群。
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Microbiota and Thyroid Interaction in Health and Disease.肠道菌群与甲状腺在健康与疾病中的相互作用
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