用于组织工程的生物材料导向细胞行为
Biomaterial-directed cell behavior for tissue engineering.
作者信息
Kim Hyun, Kumbar Sangamesh G, Nukavarapu Syam P
机构信息
Biomedical Engineering, University of Connecticut, Storrs-06269.
Materials Science & Engineering, University of Connecticut, Storrs-06269.
出版信息
Curr Opin Biomed Eng. 2021 Mar;17. doi: 10.1016/j.cobme.2020.100260. Epub 2020 Dec 25.
Successful tissue regeneration strategies focus on the use of novel biomaterials, structures, and a variety of cues to control cell behavior and promote regeneration. Studies discovered how biomaterial/ structure cues in the form of biomaterial chemistry, material stiffness, surface topography, pore, and degradation properties play an important role in controlling cellular events in the contest of and tissue regeneration. Advanced biomaterials structures and strategies are developed to focus on the delivery of bioactive factors, such as proteins, peptides, and even small molecules to influence cell behavior and regeneration. The present article is an effort to summarize important findings and further discuss biomaterial strategies to influence and control cell behavior directly via physical and chemical cues. This article also touches on various modern methods in biomaterials processing to include bioactive factors as signaling cues to program cell behavior for tissue engineering and regenerative medicine.
成功的组织再生策略侧重于使用新型生物材料、结构以及各种信号来控制细胞行为并促进再生。研究发现，生物材料化学、材料硬度、表面形貌、孔隙和降解特性等形式的生物材料/结构信号在组织再生过程中控制细胞活动方面发挥着重要作用。人们开发了先进的生物材料结构和策略，专注于递送生物活性因子，如蛋白质、肽甚至小分子，以影响细胞行为和再生。本文旨在总结重要发现，并进一步探讨通过物理和化学信号直接影响和控制细胞行为的生物材料策略。本文还涉及生物材料加工中的各种现代方法，即将生物活性因子作为信号来编排细胞行为，用于组织工程和再生医学。
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