Zhou Guoying, Xu Ruojiao, Groth Thomas, Wang Yanying, Yuan Xingyu, Ye Hua, Dou Xiaobing
College of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Biomedical Materials, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Tissue Eng Part B Rev. 2024 Dec;30(6):607-630. doi: 10.1089/ten.TEB.2024.0002. Epub 2024 Apr 12.
Regenerative medicine aims to restore the function of diseased or damaged tissues and organs by cell therapy, gene therapy, and tissue engineering, along with the adjunctive application of bioactive molecules. Traditional bioactive molecules, such as growth factors and cytokines, have shown great potential in the regulation of cellular and tissue behavior, but have the disadvantages of limited source, high cost, short half-life, and side effects. In recent years, herbal compounds extracted from natural plants/herbs have gained increasing attention. This is not only because herbal compounds are easily obtained, inexpensive, mostly safe, and reliable, but also owing to their excellent effects, including anti-inflammatory, antibacterial, antioxidative, proangiogenic behavior and ability to promote stem cell differentiation. Such effects also play important roles in the processes related to tissue regeneration. Furthermore, the moieties of the herbal compounds can form physical or chemical bonds with the scaffolds, which contributes to improved mechanical strength and stability of the scaffolds. Thus, the incorporation of herbal compounds as bioactive molecules in biomaterials is a promising direction for future regenerative medicine applications. Herein, an overview on the use of bioactive herbal compounds combined with different biomaterial scaffolds for regenerative medicine application is presented. We first introduce the classification, structures, and properties of different herbal bioactive components and then provide a comprehensive survey on the use of bioactive herbal compounds to engineer scaffolds for tissue repair/regeneration of skin, cartilage, bone, neural, and heart tissues. Finally, we highlight the challenges and prospects for the future development of herbal scaffolds toward clinical translation. Overall, it is believed that the combination of bioactive herbal compounds with biomaterials could be a promising perspective for the next generation of regenerative medicine. Impact statement This article reviews the combination of bioactive herbal compounds with biomaterials in the promotion of skin, cartilage, bone, neural, and heart regeneration, due to the anti-inflammatory, antibacterial, antioxidative, and proangiogenic effects of the herbal compounds, but also their effects on the improvement of mechanic strength and stability of biomaterial scaffolds. This review provides a promising direction for the next generation of tissue engineering and regenerative medicine.
再生医学旨在通过细胞疗法、基因疗法和组织工程，以及生物活性分子的辅助应用，恢复患病或受损组织及器官的功能。传统的生物活性分子，如生长因子和细胞因子，在调节细胞和组织行为方面显示出巨大潜力，但存在来源有限、成本高、半衰期短和副作用等缺点。近年来，从天然植物/草药中提取的草药化合物越来越受到关注。这不仅是因为草药化合物易于获得、价格低廉、大多安全可靠，还因其具有出色的效果，包括抗炎、抗菌、抗氧化、促血管生成行为以及促进干细胞分化的能力。这些作用在与组织再生相关的过程中也发挥着重要作用。此外，草药化合物的部分基团可与支架形成物理或化学键，这有助于提高支架的机械强度和稳定性。因此，将草药化合物作为生物活性分子纳入生物材料是未来再生医学应用的一个有前景的方向。本文概述了生物活性草药化合物与不同生物材料支架结合用于再生医学应用的情况。我们首先介绍不同草药生物活性成分的分类、结构和性质，然后全面综述生物活性草药化合物用于构建皮肤、软骨、骨、神经和心脏组织修复/再生支架的情况。最后，我们强调草药支架向临床转化的未来发展面临的挑战和前景。总体而言，人们认为生物活性草药化合物与生物材料的结合可能是下一代再生医学的一个有前景的方向。影响声明本文综述了生物活性草药化合物与生物材料在促进皮肤、软骨、骨、神经和心脏再生方面的结合，这不仅归因于草药化合物的抗炎、抗菌、抗氧化和促血管生成作用，还归因于它们对提高生物材料支架机械强度和稳定性的作用。这篇综述为下一代组织工程和再生医学提供了一个有前景的方向。
