类风湿关节炎患者的疾病活动度、功能能力和营养状况：希腊的一项观察性研究
Disease Activity, Functional Ability and Nutritional Status in Patients with Rheumatoid Arthritis: An Observational Study in Greece.
作者信息
Markaki Anastasia G, Gkiouras Konstantinos, Papakitsos Christos, Grammatikopoulou Maria G, Papatsaraki Athena, Ioannou Roula, Tsagkari Amalia, Papamitsou Theodora, Bogdanos Dimitrios P
机构信息
Department of Nutrition & Dietetics Sciences, Faculty of Health Sciences, Hellenic Mediterranean University, Sitia, Crete, Greece.
Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
出版信息
Mediterr J Rheumatol. 2020 Dec 28;31(4):406-411. doi: 10.31138/mjr.31.4.406. eCollection 2020 Dec.
AIM
The aim of the present pilot study was to assess differences in the nutritional status, Mediterranean diet (MD) adherence, and functional ability among patients with rheumatoid arthritis (RA), according to disease activity.
METHODS
A total of 48 patients with RA, outpatients of a hospital in Athens, Greece were recruited. Disease activity was evaluated with DAS28, functional status with the Health Assessment Questionnaire (HAQ), MD adherence with the MedDietScore and malnutrition with the patient-generated subjective global assessment (PG-SGA).
RESULTS
A relationship was noted between DAS28 and HAQ, indicating a reduced functional status with increased RA activity. Although MD adherence differed between DAS28 categories, no specific differences were noted in the PG-SGA or the MedDietScore in the post-hoc analyses. According to the PG-SGA, no need for nutritional intervention was noted among participants.
CONCLUSIONS
The origin of the participants might have reduced the differences between MD adherence and DAS28. In parallel, the PG-SGA does not appear sensitive in detecting muscle-related malnutrition among patients with RA.
目的
本初步研究旨在根据疾病活动度评估类风湿关节炎（RA）患者在营养状况、地中海饮食（MD）依从性和功能能力方面的差异。
方法
招募了希腊雅典一家医院的48名类风湿关节炎门诊患者。采用DAS28评估疾病活动度，采用健康评估问卷（HAQ）评估功能状态，采用地中海饮食评分（MedDietScore）评估MD依从性，采用患者主观整体评定法（PG-SGA）评估营养不良情况。
结果
DAS28与HAQ之间存在关联，表明随着类风湿关节炎活动度增加，功能状态下降。虽然不同DAS28类别之间的MD依从性存在差异，但事后分析中在PG-SGA或MedDietScore方面未发现具体差异。根据PG-SGA，参与者中未发现有营养干预的必要。
结论
参与者的来源可能减少了MD依从性与DAS28之间的差异。同时，PG-SGA在检测类风湿关节炎患者中与肌肉相关的营养不良方面似乎不敏感。
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